解放军医学杂志2017，Vol.42Issue(12)：1102-1105,4.DOI:10.11855/j.issn.0577-7402.2017.12.15
NLRP3炎症小体在肾缺血再灌注损伤中的作用
Progress of research on NLRP3 inflammasome in kidney ischemia-reperfusion injury
武康 1蔡明1
作者信息
- 1. 100091 北京 解放军309医院器官移植研究所泌尿外科、器官移植与免疫调节北京市重点实验室
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摘要
Abstract
Ischemia-reperfusion injury is an inflammatory cascade involving a variety of factors.It is closely related to the delayed graft function and acute rejection after renal transplantation.At present,the mechanism of ischemia-reperfusion injury is not clear.Recent studies have shown that NLRP3 inflammasome,as a key molecule of inflammatory cascade,plays an important role in the development and progression of renal ischemia-reperfusion injury.Therefore,it is expected to become a new therapeutic target for renal ischemia-reperfusion injury.This article reviews the role of NLRP3 inflammasome in renal ischemia-reperfusion injury.关键词
肾移植/缺血再灌注损伤/NLRP3炎症小体Key words
kidney transplantation/ischemia-reperfusion injury/NLRP3 inflammasome分类
医药卫生引用本文复制引用
武康,蔡明..NLRP3炎症小体在肾缺血再灌注损伤中的作用[J].解放军医学杂志,2017,42(12):1102-1105,4.
