检验医学与临床2018，Vol.15Issue(2)：145-150,6.DOI:10.3969/j.issn.1672-9455.2018.02.001
2015年山东省立医院细菌耐药性监测
Surveillance of antibiotic resistance in clinical isolates from Shandong Provincial Hospital during 2015
摘要
Abstract
Objective To investigate the resistance and distribution of bacteria of clinical isolates in Shan-dong Provincial Hospital during 2015 .Methods Except for antimicrobial susceptibility of staphylococcal strains was tested by VITEK 2 Compact ,and the disk diffusion method was used for the other strains .The re-sults were interpreted according to the CLSI 2015 M100-S25 ,and the data were analyzed by using WHONET 5 .6 software .Results A total of 4252 non-duplicate clinical strains were collected during 2015 ,of which gram-negative rods and gram-positive cocci accounted for 68 .20％ and 31 .80％ ,respectively .The detection rates of methicillin resistant staphylococcus aureus (MRSA ) and methicillin resistant coagulase negative staph-ylococci (MRSCN) were 35 .82％ and 68 .75％ ,respectively .The percentage of the E .faecium strains resistant to most antibiotics tested was higher than that of E .faecalis .We found three strains of vancomycin resistant enterococcus were E .faecium .The prevalence of ESBLs were 41 .00％ in the strains of E .coil and 24 .71％ in K .pneumoniae strains and 37 .29％ in Proteus mirabilis strains ,respectively .The resistance rate of ESBLs-positive strains was higher than ESBLs-negative strains to most antibiotics .A total of 88 carbapenem-resistant Enterobacteriaceae isolates were identified .The percentage of the P .aeruginosa strains resistant to imipenem and meropenem were 19 .7％ and 17 .6％ ,respectively .More than 40％ of the A .baumannii strains were resist-ant to all the antibiotics tested except cefoperazone (32 .3％ ) .The prevalence of β-lactamase in H .influenzae was 65 .28％ .All the S .pneumoniae strains were non-meningitis strains ,mainly isolated from children′s ward (72 .62％ ) .The higher prevalence of penicillin resistant S .pneumoniae was found in the strains isolated form children compared to the isolates from adults .Conclusion Bacterial resistance is on the rise .More attention should be paid to resistance surveillance and rational use of antibiotics .关键词
细菌耐药性/抗菌药物/泛耐药菌Key words
bacterial resistance/antimicrobial/pandrug-resistant bacteria分类
医药卫生引用本文复制引用
范会,王丽萍,金炎,张仁峰,邵春红..2015年山东省立医院细菌耐药性监测[J].检验医学与临床,2018,15(2):145-150,6.基金项目
国家自然科学基金资助项目(81401696) （81401696）
山东省重点研发计划资助项目(2016GSF201078). （2016GSF201078）
