检验医学与临床2018，Vol.15Issue(2)：164-167,4.DOI:10.3969/j.issn.1672-9455.2018.02.006
脑脊液置换联合鞘内注射治疗对结核性脑膜炎患者脑脊液 CRP和NSE水平的影响
Effect of cerebrospinal fluid replacement combined with intrathecal injection on C-reactive protein and neuron-specific enolase in patients with tuberculous meningitis
摘要
Abstract
Objective To investigate the effects of cerebrospinal fluid replacement and intrathecal injection on C-reactive protein and neuron-specific enolase in patients with tuberculous meningitis .Methods A total of 102 patients with tuberculous meningitis admitted in our hospital from January 2015 to October 2016 were en-rolled in this study .Fifty-one patients were divided into observation group and control group by method of drawing lots .The patients in the control group were given anti-tuberculosis and hepatoprotective ,hormone and other conventional treatment ,the observation group received conventional treatment based on the use of cere-brospinal fluid replacement combined with intrathecal injection treatment ,the two groups of patients before and after treatment of C-reactive protein and neuron-specific enolase levels and clinical after treatment Symp-tom relief and clinical efficacy .Results There were no significant differences in CRP and NSE between the two groups before treatment (P>0 .05) .After treatment ,the levels of CRP and NSE in the two groups were significantly lower than those in the control group .The recovery time of the headache ,the time of disappear-ance of the fever ,the time of recovery of the meningeal irritation ,the recovery time of cerebrospinal fluid pro-tein and the time required for the recovery of cerebrospinal fluid were significantly better than those of the control group .The total effective rate was 96 .08％ (49/51) ,which was significantly higher than that of the control group 80 .39％ (41/51) ,the above differences were statistically significant (P< 0 .05) .Conclusion The combination of cerebrospinal fluid replacement and intrathecal injection in patients with tuberculous men-ingitis can significantly reduce the levels of C-reactive protein and neuron-specific enolase ,and the curative effect is significant .Worthy of clinical use .关键词
结核性脑膜炎/脑脊液/鞘内注射/C反应蛋白/神经元特异性烯醇化酶Key words
tuberculous meningitis/cerebrospinal fluid replacement/intrathecal injection therapy/C-reactive protein/neuron-specific enolase分类
医药卫生引用本文复制引用
张建树,李倩,孟艺哲..脑脊液置换联合鞘内注射治疗对结核性脑膜炎患者脑脊液 CRP和NSE水平的影响[J].检验医学与临床,2018,15(2):164-167,4.基金项目
河北省青年科技课题资助项目(20150140). （20150140）
