检验医学与临床2018，Vol.15Issue(2)：186-188,3.DOI:10.3969/j.issn.1672-9455.2018.02.013
坦度螺酮联合氟哌啶醇治疗对酒精所致精神障碍患者
BDNF和NGF水平的影响
Effect of combination of tandospirone and haloperidol on the levels of BDNF and NGF in patients with mental disorders due to alcohol
刘建洪1
作者信息
- 1. 云南省传染病专科医院精神3科,云南安宁650301
- 折叠
摘要
Abstract
Objective To investigate the effects of halftamol combined with haloperidol on serum brain-de-rived neurotrophic factor (BDNF) and serum nerve growth factor (NGF) in patients with mental disorders caused by alcoholism .Methods 80 patients with mental disorders caused by alcoholism were selected from Yunnan Infectious Disease Specialist Hospital ,they were randomly divided into haloperidol group (treated with haloperidol) and combined treatment group (treated with buspirone combined with haloperidol ) ,40 cases in each group .The therapeutic effect was evaluated after 6 weeks of drug treatment ,and the changes of BDNF and NGF in serum were measured by enzyme linked immunosorbent assay (ELISA) method before and after treatment .The positive and negative symptom scores before and after treatment were observed and compared . Results Serum BDNF and NGF concentrations were significantly increased after haloperidol treatment and combination therapy .The levels of serum BDNF and NGF increased more significantly after treatment with tandospirone and haloperidol (P<0 .05) .Patients in the haloperidol treatment and combination therapy signif-icantly reduced PANSS score ;Compared with the haloperidol group ,PANSS scores were significantly lower in patients treated with tandospirone and haloperidol (P<0 .05) .Conclusion Tandospirone combined with halo-peridol has significant effects on serum BDNF and NGF levels in mental disorders caused by alcoholism .And halftamol combined with haloperidol effectively reduced the PANSS score in patients with mental disorders caused by alcohol .关键词
酒精/精神障碍/脑源性神经营养因子/神经生长因子Key words
alcohol/mental disoraers/BDNF/NGF分类
医药卫生引用本文复制引用
刘建洪..坦度螺酮联合氟哌啶醇治疗对酒精所致精神障碍患者
BDNF和NGF水平的影响[J].检验医学与临床,2018,15(2):186-188,3.
