检验医学与临床2018，Vol.15Issue(2)：195-197,201,4.DOI:10.3969/j.issn.1672-9455.2018.02.016
富马酸喹硫平片联合碳酸锂对双相情感障碍躁狂发作
患者认知功能的影响
The effect of quetiapine fumarate tablets effect combined with lithium carbonate in the cognitive function of the patients with manic episodes of bipolar disorder
马建英 1杨勇1
作者信息
- 1. 江苏省连云港市康复医院精神科 222003
- 折叠
摘要
Abstract
Objective To investigate the effect of quetiapine fumarate tablets combined with lithium car-bonate in the cognitive function of the patients with manic episodes of bipolar disorder .Methods From Sep-tember 2014 to September 2016 in our hospital treatment of 90 cases of manic episode of bipolar disorder pa-tients were divided into two groups .The control group was treated with ithium carbonate treatment ,observa-tion group was treated with quetiapine and lithium carbonate combined treatment .Two groups were compared before and after treatment of the Bech-Rafaelsen Mania Rating Scale (BRMS) score ,clinical efficiency ,cogni-tive function (including execution ,memory ,attention ) ,inflammatory cytokines [tumor necrosis factor α(TNF-α) ,interleukin-4 (IL-4) ,interleukin-10 (IL-10)] and other indicators .Results BRMS score and clinical efficacy :BRMS scores after treatment were significantly lower than that before treatment in two groups of pa-tients(P<0 .05) .The BRMS score and clinical efficacy of the observation group were significantly better than those of the control group ,the difference was statistically significant (P< 0 .05) .Cognitive function :two groups of patients before and after the level of implementation (WCST test value) ,memory level (HVLT-R test value) were not significantly improved (P>0 .05) .But the level of attention (CPT test) improved signifi-cantly (P<0 .05) .And the observation group was significantly better than the control group (P<0 .05) .In-flammatory factors :in two groups of patients before and after treatment ,TNF-α,IL-4 levels were significantly decreased (P<0 .05) ,IL-10 levels were significantly higher (P<0 .05) .After treatment ,TNF-α and IL-1 in the observation group were significantly lower than those in the control group ,and IL-10 was significantly higher than that in the control group .The difference was statistically significant (P<0 .05) .There was no sig-nificant difference in the incidence of adverse reactions between the two groups (P>0 .05) .Conclusion the combination of quetiapine fumarate tablets and lithium carbonate can significantly improve the cognitive func-tion of patients with manic episode of bipolar disorder ,and decreased the BRMS score and obviously improve the level of inflammatory factors .关键词
双相情感障碍/躁狂/富马酸喹硫平/碳酸锂Key words
bipolar disorder/mania/quetiapine/lithium carbonate分类
医药卫生引用本文复制引用
马建英,杨勇..富马酸喹硫平片联合碳酸锂对双相情感障碍躁狂发作
患者认知功能的影响[J].检验医学与临床,2018,15(2):195-197,201,4.
