摘要
Abstract
Objective To analyze the recent mid term curative effect of Thymosin combined with pyrazi-namide in treatment of multi-drug resistant tuberculosis and the influence on immunologic function .Methods A retrospective study was conducted ,87 patients with multi-drug resistant tuberculosis in our hospital from January 2013 to January 2015 were collected ,the clinical data were analyzed ,the patients were divided into two groups according to different treatment protocols :All patients were treated with conventional antituberculosis regimen ,the control group(n=41) was treated with pyrazinamide ,the observation group(n=46) was treated with thymosin combined with pyrazinamide .The sputum negative conversion rate ,the response rates of focal absorption and cavity occlusion ,immunologic function were compared between the two groups .Results After 6 ,12 and 24 months of therapy ,the sputum negative conversion rate of the observation group were 63 .04％ , 78 .26％ and 91 .30％ ,respectively ,which were significantly higher than those of 41 .46％ ,56 .10％ and 73 .17％ in the control group (P<0 .05);After 12 and 24 months of therapy ,the response rate of cavity occlu-sion were 77 .27％ and 84 .09％ ,respectively ,which were significantly higher than those of 55 .26％ and 63 .16％ in the control group (P<0 .05);After 12 and 24 months of therapy ,the response rate of focal absorp-tion were 76 .09％ and 89 .13％ ,respectively ,which were significantly higher than those of 53 .66％ and 68 . 29％ (P<0 .05);After 6 months of therapy ,the CD3+ ,CD4+ T cells and CD4+ /CD8+ of observation group were significantly higher than those of the control group ,the CD8+ T cells was significantly lower than that of the control group (P<0 .05) .Conclusion Thymosin combined with pyrazinamide in treatment of multi-drug resistant tuberculosis and promote the focus absorption ,sputum conversion and cavity closure ,enhance the im-mune function of patients ,improve patients near the middle of effect ,and did not increase adverse reactions .关键词
耐多药肺结核/吡嗪酰胺/胸腺肽/免疫功能Key words
multi-drug resistant tuberculosis/pyrazinamide/thymosin/immunologic function分类
医药卫生
