检验医学与临床2018，Vol.15Issue(2)：213-216,4.DOI:10.3969/j.issn.1672-9455.2018.02.021
非小细胞肺癌患者血清CYfra21-1、CEA、NSE手术前后的水平变化及意义
The value of serum CYfra21-1 ,CEA and NSE levels in patients with non-small cell lung cancer
高洋 1张启知 1凌建华 1李汝林 1武亮 1王华国2
作者信息
- 1. 四川省资阳市第一人民医院 胸心外科 641300
- 2. 四川省资阳市第一人民医院 检验科 641300
- 折叠
摘要
Abstract
Objective To study the expression changes and significance of serum cytokeratin 19 fragment (CYfra21-1) ,carcino embryonic antige(CEA)and neuron specific enolase(NSE)before and after operation in the patients with non-small-cell lung cancer(NSCLC) .Methods Ninety-six patients with non-small cell lung cancer(NSCLC) admitted in our hospital from January 2014 to December 2015 were enrolled in this study .En-zyme linked immunosorbent assay(ELISA) was used to detect the levels of serum CYfra21-1 ,CEA and NSE before and after the operation of the patients ,and the levels were measured and analyzed statistically .Results The levels of CYfra21-1 ,CEA and NSE in patients were lower than those before operation ,and the difference was statistically significant (P<0 .05) .Patients were divided into subgroups according to pathological type and stage .The concentration and positive rate of the three cytokines showed the same trend as before grouping , that was ,the difference was statistically significant (P<0 .05) .Conclusion The serum levels of CYfra21-1 , NSE and CEA can be used to assess the efficacy of operation in patients with NSCLC and monitor patients condition and prognosis .It′s great significance for clinical treatment ,worthy of clinical popularization and ap-plication .关键词
非小细胞肺癌/细胞角蛋白19片段/癌胚抗原/神经元特异性烯纯化酶Key words
non-small cell lung cancer/cytokeratin 19 fragment/carcinoembryonic antige/neuron specific enolase分类
医药卫生引用本文复制引用
高洋,张启知,凌建华,李汝林,武亮,王华国..非小细胞肺癌患者血清CYfra21-1、CEA、NSE手术前后的水平变化及意义[J].检验医学与临床,2018,15(2):213-216,4.
