临床眼科杂志2017，Vol.25Issue(6)：569-572,4.DOI:10.3969/j.issn.1006-8422.2017.06.026
蛋白质组学应用于糖尿病视网膜病变发病机制的研究进展
Progress of proteomics applied to the pathogenesis of diabetic retinopathy
摘要
Abstract
Diabetic retinopathy (DR),a leading cause of acquired vision loss,is a microvascular complication of diabetes.While traditional risk factors for diabetic retinopathy including longer duration of diabetes,poor blood glucose control,and dyslipidemia are helpful in stratifying patient's risk for developing retinopathy,many patients without these risk factors develop DR;furthermore,there are persons with long diabetes duration who do not develop DR.Actually,The overall development of DR is multifactorial,with a complex interplay of microvascular,neurodegenerative,immunological,and secondary inflammation-related factors.A biomarker can be defined as a characteristic that is objectively measured and evaluated as an indicator of normal biological processes,pathogenic processes,or pharmacologic responses to a therapeutic intervention.Understanding the molecular events leading to the eye complications caused by hyperglycemia may help the identification of novel biomarkers as well as therapeutic targets.Proteomics is a scientific discipline which can analysis the composition,function and the relationship among proteins in cells,tissues,body fluids in a high flux,quickly identify,quantitative analytic way.In this work we have reviewed the administration of advanced proteomics techniques used in biomarker studies and the identified biomarkers with potential to improve the already existing screening methods for DR detection.关键词
蛋白质组学/糖尿病视网膜病变/生物标志物Key words
Proteomics/Diabetic retinopathy/biomarkers引用本文复制引用
张媛,金玮,杨安怀..蛋白质组学应用于糖尿病视网膜病变发病机制的研究进展[J].临床眼科杂志,2017,25(6):569-572,4.基金项目
湖北省卫生和计划生育委员会重点项目(项目编号:WJ2015MA008) （项目编号:WJ2015MA008）
