山东中医杂志2018，Vol.37Issue(2)：156-160,5.DOI:10.16295/j.cnki.0257-358x.2018.02.020
强心颗粒抑制慢性心力衰竭心气虚兼血瘀水肿证模型大鼠心肌细胞凋亡实验研究
Experimental Study of Qiangxin Granules Inhibiting Cardiomyocytes Apoptosis in Rat Model of Chronic Heart Failure with Heart Qi Deficiency ,Blood Stasis and Edema Syndrome
摘要
Abstract
Objective:To study the curative effect of Qiangxin granules(QXP) on inhibiting cardiomyocytes apoptosis of rats with chronic heart failure of heart qi deficiency complicated with blood stasis and edema syndrome(HQD-BS-ES). Methods:Eighty SD rats were randomly divided to normal group(n=20) and chronic heart failure of HQD-BS-ES group(n=60) which was established by administering adriamycin plus propylth-iouracil. And then the latter were randomly divided to 3 groups including model control group(n=18),valsar-tan(VAL) group (n=18) and QXP group (n=18). The survival rate,lactate dehydrogenase (LDH),reactive oxy-gen species (ROS),malondialdehyde (MDA),superoxide dismutase (SOD),apoptosis index and Rac1 relative content were evaluated and compared. Results:Compared with the control group,the survival rate, LDH,ROS,MDA,SOD,apoptosis index and Rac1 re-lative content in other groups improved significantly (P<0.05). Compared with the model group,the su-rvival rate,LDH,ROS,MDA,SOD,apoptosis index and Rac1 relative content of the QXP group improved significantly(P<0.05). Compared to VAL group,the survival rate and LDH of the QXP group showed no statistical difference,while the ROS,MDA,SOD,apoptosis index and Rac-1 relative content of the QXP group improved significantly (P<0.05). Conclusion:QXP has a good effect on inhibiting cardiomyocytes apoptosis induced by oxidative stress ,which could be an important mechanism of QXP for curing chronic heart failure of HQD-BS-ES.关键词
强心颗粒/慢性心力衰竭/心气虚兼血瘀水肿证/心肌细胞凋亡/氧化应激Key words
Qiangxin granules/chronic heart failure/heart qi deficiency complicated with blood stasis and edema syndrome/cardiomyocytes apoptosis/oxidative stress分类
医药卫生引用本文复制引用
房丽君,李珩,胡文玉,周杰,林家茂..强心颗粒抑制慢性心力衰竭心气虚兼血瘀水肿证模型大鼠心肌细胞凋亡实验研究[J].山东中医杂志,2018,37(2):156-160,5.基金项目
山东省自然科学基金重点项目(编号:ZR2009CZ007) （编号:ZR2009CZ007）
山东省自然科学基金中青年科学家奖励基金(编号:ZR2016HB 60) （编号:ZR2016HB 60）
山东省医学科学院院级科技计划项目(编号:2014-13) （编号:2014-13）
