山东中医杂志2018，Vol.37Issue(2)：161-164,4.DOI:10.16295/j.cnki.0257-358x.2018.02.021
金荞麦多酚分散片处方优选及溶出度研究
Study on Optimizing Formulation of Jimqiamai (Rhizoma Fagopyri Dibotryis) Polyphenol Dispersible Tablets and Its Dissolvability
摘要
Abstract
Objective:To optimize the formulation of Jinqiaomai (rhizoma fagopyri dibotryis ) polyphenol dis-persible tablets and to study its dissolvability. Methods:In terms of disintegration time the types of filler and disintegrant were optimized by single factor experiment and the dosage of the excipients was optimized by orthogonal test. The dissolvability of rhizoma fagopyri dibotryis polyphenol dispersible tablets was investi-gated by using epicatechin and procyanidins as the indicators. Results:The optimized formulation was com-posed of the extract powder 34.2％,microcrystalling cellulose 50％,polyvinylpolyrrolidone 15％,magnesium stearate 0.8％. The disintegration time of the optimized formulation was less than 3 minutes ,the dissolvability of epicatechin and procyanidins in 3 minutes was more than 85％,the dissolvability of procyanidins reached 100％ in 5 minutes,and the dissolvability of epicatechin in 10 minutes reached 100％. Conclusion:This rhi-zoma fagopyri dibotryis dispersible tablets with the optimized formulation dissolves quickly with good dissolv-ability.关键词
金荞麦/分散片/处方优选/表儿茶素/溶出度Key words
rhizoma fagopyri dibotryis/dispersible tablet/optimized formulation/epicatechin/dissolvability分类
医药卫生引用本文复制引用
张元元,王绍花,韩真真,盛华刚..金荞麦多酚分散片处方优选及溶出度研究[J].山东中医杂志,2018,37(2):161-164,4.基金项目
山东省高校中医药抗病毒协同创新中心项目(编号:XTCX2014C02-08) （编号:XTCX2014C02-08）
山东省高等学校科技计划项目(编号:J11LF30) （编号:J11LF30）
山东中医药大学"名科工程"青年骨干培养计划课题(编号:ZYDXY1341) （编号:ZYDXY1341）
