山东医药2017，Vol.57Issue(37)：21-24,4.DOI:10.3969/j.issn.1002-266X.2017.37.007
支气管哮喘患儿血浆H2S水平变化及意义
Changes of plasma H2S levels in children with bronchial asthma
摘要
Abstract
Objective To observe the changes of plasma hydrogen sulfide (H2S) levels in children with bronchial asthma and to explore its clinical significance.Methods A total of 76 children with bronchial asthma (acute exacerbation group) were divided into the mild acute exacerbation group (n =33),moderate acute exacerbation group (n =24),and severe acute exacerbation group (n =19) according to the condition of children admitted to hospital.Meanwhile,41 of children with asthma remission were selected as the asthma remission group and 50 healthy subjects as the control group.The lung function and induced sputum cell count in each group was measured.The level of plasma H2S was determined by UV Visible spectrophotometry,and the levels of TNF-α and IL-6 in the plasma were determined by enzyme-linked immunosorbent assay.Pearson product moment correlation was used to analyze the relationship between plasma H2S levels and other indexes.Results The lung function indicators of the acute exacerbation group were lower than those of the control group,asthma remission group (all P ＜ 0.05).The percentage of total cells,percentage of neutrophils,percentage of eosinophils,plasma levels of TNF-α and IL-6 in the acute exacerbation group and asthma remission group were higher than those in the control group(P ＜0.05),while the percentage of macrophages and the plasma H2S level in the acute exacerbation group and asthma remission group were lower than those in the control group (both P ＜ 0.05),and the changes of the above indicators were more significant in the acute exacerbation group (all P ＜ 0.05).What's more,with the condition increase of bronchial asthma,the above indicators changed more obviously (P ＜ 0.05).Among the children with acute exacerbation of bronchial asthma,the plasma H2S level was positively correlated with the lung function parameters and the percentage of macrophages (both P ＜ 0.05),and were negatively correlated with the total cells,the percentage of neutrophils,percentage of eosinophils,and the levels of TNF-α and IL-6 (all P ＜ 0.05).Conclusions The level of plasma H2S in children with bronchial asthma decreases.The more serious the conditions of bronchial asthma becomes,the lower the plasma H2S level is.关键词
支气管哮喘/硫化氢/肿瘤坏死因子α/白细胞介素6Key words
bronchial asthma/hydrogensulfide/tumor necrosis factor-α/interleukin-6分类
医药卫生引用本文复制引用
黄海英,何庆娟,孙宝兰,陈尚明..支气管哮喘患儿血浆H2S水平变化及意义[J].山东医药,2017,57(37):21-24,4.基金项目
江苏省卫生厅面上科研课题(H201589). （H201589）
