山东医药2018，Vol.58Issue(1)：1-4,4.DOI:10.3969/j.issn.1002-266X.2018.01.001
2型糖尿病合并高血压患者血清分泌型卷曲相关蛋白5水平与血压分级及左心室肥大的关系
Correlation between serum sfrp5 and left ventricular hypertrophy in patients with T2DM complicated with different classifications of hypertension
摘要
Abstract
Objective To investigate the changes of serum secreted frizzled-related protein-5 (sfrp5) and its correlation with left ventricular hypertrophy in patients with type 2 diabetes mellitus (T2DM) and different classifications of hypertension. Methods A total of 200 subjects were divided into the normal control group (NC group), T2DM without hypertension group (DS group), T2DM with grade 1 hypertension group (H1 group), T2DM with grade 2 hypertension group (H2 group), and T2DM with grade 3 hypertension group (H3 group).We determined the levels of serum sfrp5 and used the echocardiogram to ob-serve the changes of cardiac structure and function in each group .Results The early diastolic and late diastolic peak velocity ratio (E/A) and sfrp5 decreased in the DS, H1, H2, and H3 groups as compared with that of the NC group (both P<0.05). E/A and sfrp5 were significantly lower in the H1, H2, and H3 groups than in the DS group, and gradually decreased with the in-crease of blood pressure classification (both P<0.05).The left ventricular mass index (LVMI) was higher in the DS, H1, H2, and H3 groups than in the NC group (all P<0.05).The LVMI in the H1, H2, and H3 groups were greater than that in the DS group, and the LVMI gradually increased with the increase of blood pressure (all P<0.05).Multiple linear regression analysis showed that serum sfrp5 level was negatively correlated with LVMI, SBP, and DBP (r=-0.260,-0.160,-0.290;P<0.05). Conclusions With the increase of blood pressure classification , the serum sfrp5 decreases but the LVMI increases .Sfrp5 plays an important role in the change of left ventricular hypertrophy in patients with T2DM and hypertension.关键词
2型糖尿病/高血压/肥大,左心室/血压分级/分泌型卷曲相关蛋白5Key words
diabetes mellitus,type 2/hypertension/left ventricular hypertrophy/different classification/secreted frizzled-related protein-5分类
医药卫生引用本文复制引用
张鑫,李宝新,张云良,常文龙,王翯,马爽,郭淑芹..2型糖尿病合并高血压患者血清分泌型卷曲相关蛋白5水平与血压分级及左心室肥大的关系[J].山东医药,2018,58(1):1-4,4.基金项目
国家自然科学基金资助项目( 81500644 ) （ 81500644 ）
河北省医学科学研究重点课题计划( 20160282 ) （ 20160282 ）
保定市科学技术研究与发展指导计划(17ZF036). （17ZF036）
