山东医药2018，Vol.58Issue(1)：9-11,3.DOI:10.3969/j.issn.1002-266X.2018.01.003
大剂量维生素C对脓毒症患者心肌损伤的作用及机制
Effect of high-dose vitamin C on myocardial injury of patients with sepsis
摘要
Abstract
Objective To observe the therapeutic effect of high-dose vitamin C on myocardial injury of patients with sepsis and to explore its possible mechanism .Methods Forty patients with myocardial injury after severe sepsis were di-vided into the observation group and control group , In the observation group , vitamin C (10g) was given intravenously for 7 days.In the control group, vitamin C (2g) was given intravenously for 7 days.The systolic blood pressure and heart rate were monitored on the first day and the eighth day , and we also observed the concentration changes of creatine kinase isoenzyme (CK-MB), troponin I (cTnI), type B urine sodium peptide (BNP), vitamin C, malondialdehyde (MDA), and superoxide dismutase (SOD) in the plasma at the two time points.Results The systolic blood pressure, vitamin C, and SOD significantly increased , while the heart rate , cTnI, BNP, and MDA significantly decreased in both of the two groups after treatment of 7 days as compared with those before treatment (all P<0.05), meanwhile, in the observation group, the increasing and decreasing amplitude was significantly higher than that in the control group (all P<0.05).In the observation group, the concentration of vitamin C tended to normal lever [(50-70) μmol/L] after 7 days.No signifi-cant difference was found in the CK-MB between these two groups before and after treatment (P>0.05).Conclusions High-dose of vitamin C has protective effect on myocardial injury after sepsis by alleviating the oxidative stress .关键词
脓毒症/心肌损伤/氧化应激Key words
sepsis/myocardia1 injury/oxidative stress分类
医药卫生引用本文复制引用
占钻,黄亮,曹春水,殷勤,刘勇,刘坚..大剂量维生素C对脓毒症患者心肌损伤的作用及机制[J].山东医药,2018,58(1):9-11,3.基金项目
江西省卫生计生委科技计划资助项目(700955002). （700955002）
