生物技术通报2018，Vol.34Issue(1)：60-66,7.DOI:10.13560/j.cnki.biotech.bull.1985.2017-0649
线粒体表观遗传学研究进展
Research Progress on Mitochondrial Epigenetics
摘要
Abstract
As the"power house"in the cell,mitochondrion is the main organelle to carry out the reaction of oxidative phosphorylation and to generate most of the ATP. Traditionally,it is suggested that mitochondria was lack of any epigenetic mechanism,but the discovery of DNA methyltransferase,5-methylcytosine,and 5-hydroxymethylcytosine in mammalian mitochondria in 2011 contradicted with this statement. In mitochondria,the DNA methyltransferase and the patterns of both DNA methylation and DNA hydroxymethylation are quite different compared with the nuclear genome DNA,and the changes of environmental factors would cause the impacts on the mitochondrial DNA methylation . In addition,epigenetic factors of mitochondrial DNA also include mitochondrial long noncoding RNA,mitochondrial miRNA and mitochondrial DNA binding protein. With the continuous improvement of research techniques,the use of mitochondrial DNA methylation as biomarker will become more extensive and its association with nuclear epigenetics will be further revealed.关键词
线粒体DNA/表观遗传学/5-甲基胞嘧啶/5-羟甲基胞嘧啶Key words
mitochondrial DNA(mtDNA)/epigenetics/5-methylcytosine/5-hydroxymethylcytosine引用本文复制引用
柳莹,高丽,冯俊荣..线粒体表观遗传学研究进展[J].生物技术通报,2018,34(1):60-66,7.基金项目
农业部渔业种质资源保护项目(HX15K11),山东省近海重要渔业资源评估项目(HX15K06),烟台大学教学研究改革项目(JYXM2016029) （HX15K11）
