天津中医药2018，Vol.35Issue(1)：72-76,5.DOI:10.11656/j.issn.1672-1519.2018.01.19
基于"异病同治"理论的银杏叶提取物及其活性成分防治心脑血管疾病共同靶标分析
Common target analysis of Ginkgo biloba extract and its active ingredients for co-treatment of cardiovascular and cerebrovascular diseases based on"same treatment for different diseases"theory
摘要
Abstract
Accumulating studies on the pharmacological activities of Ginkgo biloba extract (EGb) and its active ingredients have provided solid evidences on their roles in prevention and treatment of cardiovascular and cerebrovascular diseases. At present, correlation between cardiovascular and cerebrovascular diseases is becoming one of the most active research areas internationally. Literature search and analyses indicated that earlier investigations on EGb and its active ingredients focused on individual diseases with more attention paid to cerebrovascular disease than cardiovascular disease. Using the tool of IPA (ingenuity pathway analysis), we have attempted to reanalyze the literature on Ginkgo biloba extract and its active components with a focus on the interaction between cardiovascular and cerebrovascular disease targets. The results showed that EGb and its active components had different effects on distinct heart and brain targets but their common targets include key molecules for the pathogenesis of atherosclerosis, suggesting that EGb and its active ingredients mayshare different or the same targets to prevent and treat cardiovascular and cerebrovascular diseases. Future in-depth investigation may shed new light on EGb and its active ingredients for the co-treatment of cardiovascular and cerebrovascular diseases based on"same treatment for different diseases"theory关键词
银杏叶提取物/心血管疾病/脑血管疾病/靶标Key words
ginkgo biloba extract/cardiovascular disease/cerebral vascular disease/target分类
医药卫生引用本文复制引用
石鑫慧,吕明,朱彦..基于"异病同治"理论的银杏叶提取物及其活性成分防治心脑血管疾病共同靶标分析[J].天津中医药,2018,35(1):72-76,5.基金项目
国家973基础研究计划(2014CB542902) （2014CB542902）
科技部国家国际合作专项(2013DFA31620). （2013DFA31620）
