西北国防医学杂志2017，Vol.38Issue(12)：771-775,5.DOI:10.16021/j.cnki.1007-8622.2017.12.001
循环肿瘤细胞的HER2分型对转移性乳腺癌患者预后的影响研究
Prognostic significance of HER2 classification of circulating tumor cells in patients with metastatic breast cancer
郭宇 1刘革 1郝跃文 2刘一雄2
作者信息
- 1. 三门峡市中心医院,河南三门峡 472000
- 2. 第四军医大学西京医院病理科
- 折叠
摘要
Abstract
Objective:To evaluate the expression levels of human epidermal growth factor receptor 2 (HER2) in patients with metastatic breast cancer (MBC) by circulating tumor cells (CTC) technology assessment,and to provide the basis for the next treatment.Methods:A total of 100 patients with CTC positive MBC were selected.The expression of CTCs HER2 was detected by immunofluorescence staining,the primary tumor and metastatic of HER2 were detected by immunohistochemical staining,and the survival of the two was compared.Results:The positive rate of CTC-HER2 was 37％ (37/100),8 of which were positive for PRIM-HER2.The progression free survival time in CTC-HER2 positive patients was significantly longer than that in CTC-HER2 negative patients (P ＜ 0.01),but there was no significant difference in overall survival between the two groups.Conclusion:The status of HER2 may be altered in the progression of breast cancer.The detection of CTC can be used as a simple method to assess the level of HER2,and has a potential guiding role in the clinical treatment of breast cancer.关键词
转移性乳腺癌/循环肿瘤细胞/人类表皮生长因子受体2/生存率Key words
metastatic breast cancer/circulating tumor cells/human epidermal growth factor receptor 2/survival rate分类
医药卫生引用本文复制引用
郭宇,刘革,郝跃文,刘一雄..循环肿瘤细胞的HER2分型对转移性乳腺癌患者预后的影响研究[J].西北国防医学杂志,2017,38(12):771-775,5.
