西北国防医学杂志2017，Vol.38Issue(12)：796-798,3.DOI:10.16021/j.cnki.1007-8622.2017.12.007
卡介苗联合透明质酸灌注治疗膀胱肿瘤疗效分析
Curative effect analysis of BCG combined with hyaluronic acid perfusion in treatment of bladder tumor
孙航 1余良 1张惠敏 1蒋少华 1孙文 1周春辉 1吕晓辉1
作者信息
- 1. 解放军第三医院泌尿外科,陕西宝鸡 721000
- 折叠
摘要
Abstract
Objective:To investigate the therapeutic efficiency of bacille calmette-guerin (BCG) combined with hyaluronic acid (HA) perfusion in treatment of bladder tumor.Methods:Sixty-two patients with non muscle invasive bladder cancer (NMIBC) were randomly divided into experimental group (n--33) and control group (n =29).All the patients were received BCG perfusion 100 mg after transurethral resection of bladder tumor (TURBT) one week.The experimental group was given 40 mg HA/50 ml saline,while the control group were given 50 ml saline.Overactive bladder symptom score (OABSS) and visual analogue scale (VAS) score were recorded 3 and 6 months postoperative.Results:After perfusion 3 month,the OABSS score of experimental group was lower than that in control group,but the difference was not significant (P ＞ 0.05),however,the VAS score was significantly lower (P ＜ 0.05).No recurrences were found in both groups.After perfusion 6 month,the OABSS and VAS scores and differentials between these two scores before preperfusion were both significantly lower in experimental group than those in the control group (P ＜ 0.01).There were seven recurrent cases in the experimental group and six cases in the control group,the differences were not statistically significant (P ＞0.05).Conclusion:HA perfusion can reduce the symptoms caused by BCG,and the recurrence rate is controlled.The combination of BCG and HA may become a new perfusion therapeutic method for NMIBC patients after TURBT.关键词
膀胱肿瘤/透明质酸/卡介苗/膀胱过度活动症/膀胱疼痛综合征Key words
bladder cancer/hyaluronic acid/bacille calmette-guerin/overactive bladder symptom/bladder pain syndrome分类
医药卫生引用本文复制引用
孙航,余良,张惠敏,蒋少华,孙文,周春辉,吕晓辉..卡介苗联合透明质酸灌注治疗膀胱肿瘤疗效分析[J].西北国防医学杂志,2017,38(12):796-798,3.
