应用化学2018，Vol.35Issue(1)：21-27,7.DOI:10.11944/j.issn.1000-0518.2018.01.170338
蛋氨酸亚砜/蛋氨酸亚砜还原酶荧光检测研究进展
Research Progress on Fluorescence Detection of Methionine Sulfoxide/Methionine Sulfoxide Reductases
摘要
Abstract
As a new type of protein redox-based post-translational modification acting as a molecular switch for the modulation of protein functions , the protein methionine sulfoxidation not only acts as a biomarker of cellular oxidative stress , but also regulates redox signaling transductions , which is thus closely related to many diseases , especially neurodegenerative diseases .In many organisms , the only molecule known to reduce the methionine sulfoxide is methionine sulfoxide reductases ( Msrs ) , which can repair the oxidation damage and recover the function of protein thus play important roles in cellular redox balance regulations .In this article, we will first discuss the structure and catalytic mechanism of protein methionine sulfoxide(MetO) and Msrs, then review the recently developed fluorescent probes for MetO/Msrs type A(MsrA), and give a brief prospect at the last.关键词
蛋氨酸亚砜/氧化应激/神经退行性疾病/蛋氨酸亚砜还原酶/荧光探针Key words
methionine sulfoxide/oxidative stress/neurodegeneration diseases/methionine sulfoxide reductase/fluorescent probe分类
化学化工引用本文复制引用
徐玉林,刘春荣..蛋氨酸亚砜/蛋氨酸亚砜还原酶荧光检测研究进展[J].应用化学,2018,35(1):21-27,7.基金项目
国家自然科学基金(21502064)资助 Supported by the Nationan Natural Science Foundation of China(No.21502064) （21502064）
