应用化学2018，Vol.35Issue(1)：68-74,7.DOI:10.11944/j.issn.1000-0518.2018.01.170030
新型氨基酸衍生物手性固定相的制备及应用
Preparation and Application of Novel Bonded L-Valine and L-Alanine Derived Chiral Stationary Phases
摘要
Abstract
Ten novel amino acid derived chiral stationary phases (CSPs), including eight amino acid modified triazine derived CSPs ( CSP-1 ～CSP-8 ) and two N-p-methylbenzoyl L-amino acid CSPs ( CSP-9 ～CSP-10 ) , were prepared from L-valine and L-alanine .The chiral recognition ability of these CSPs was evaluated for regioisomers of o-, m-, p-nitrophenol and six racemates of naproxen ethyl ester , propiconazole , difenoconazole, tebuconazole, hexaconazole, 1,1′-bi-2-naphthol, under normal phase mode .The results show that CSP-1～CSP-3 and CSP-6～CSP-8 exhibit good selectivity for three regioisomers of nitrophenol .The CSPs obtained from L-alanine show better enantioselective recognition toward the racemates , which leads to a baseline separation of naproxen ethyl ester on CSP-6 .Meanwhile , the binding mode and association energy of L-alanine three-substituted triazine derivative CSP Ⅵ with R or S naproxen ethyl ester were investigated by computational simulation with Gaussian 09 software , and hydrogen bonding was found to be a significant factor on the enantioselective recognition .关键词
氨基酸衍生物/手性固定相/手性拆分/Gaussian09Key words
amino acid derivatives/chiral stationary phases/chiral separation/Gaussian 09分类
化学化工引用本文复制引用
韩小茜,蔺云云,李臻,刘文华,石宁宁,王农..新型氨基酸衍生物手性固定相的制备及应用[J].应用化学,2018,35(1):68-74,7.基金项目
国家自然科学基金项目(21462024)资助 Supported by the National Natural Science Foundation of China(No.21462024) （21462024）
