诊断学理论与实践2017，Vol.16Issue(6)：582-586,5.DOI:10.16150/j.1671-2870.2017.06.004
高盐摄入及补钾干预对盐敏感个体血压昼夜节律的影响
Effects of salt loading and potassium supplement on circadian blood pressure profile in salt-sensitive Chinese subjects
摘要
Abstract
Objective:Salt-sensitive subjects showed more frequently a non-dipper blood pressure pattern.This study aimed to investigate whether potassium supplement can improve the blunted nocturnal blood pressure fall in salt-sensitive patients exposed to high-salt diet.Methods:A total of 49 normotensive and mildly hypertensive Chinese patients received a study protocol of a 3 d baseline examination,7 d low salt diet (51.3 mmol/d NaCl),7 d high salt diet (307.7 mmol/d NaCl) and 7 d high salt diet with a potassium supplement (307.7 mmol/d NaCl and 60 mmol/d KCl).The blood pressure of the subjects was measured at the end of each period,and blood and urine samples were collected.The 24 h ambulatory blood pressure was also obtained.Results:Of all the 49 subjects,the detection rate of salt-sensitive individuals was 28.6％.The night-to-day blood pressure ratio was significantly higher in salt-sensitive subjects than in non-salt-sensitive ones during the high salt loading period (systolic blood pressure 0.96±0.01 vs 0.89±0.01,P＜0.01;diastolic blood pressure 0.96±0.01 vs 0.92±0.01,P＜0.05).Compared with the high-salt loading period,night-to-day blood pressure ratio was significantly decreased by potassium supplement in salt-sensitive subjects (systolic blood pressure 0.91±0.01 vs 0.96±0.01,P＜0.05;diastolic blood pressure 0.91±0.01 vs 0.96±0.01,P＜0.05).Conclusions:Potassium supplement can improve the blunted nocturnal blood pressure fall in salt sensitive patients exposed to high-salt diet.关键词
盐敏感/动态血压/高盐/补钾/夜间/白天血压比Key words
Salt-sensitive/Ambulatory blood pressure/High salt/Potassium supplement/Night-to-day blood pressure ratio分类
医药卫生引用本文复制引用
郭统帅,褚超,汪洋,任珂宇,牟建军..高盐摄入及补钾干预对盐敏感个体血压昼夜节律的影响[J].诊断学理论与实践,2017,16(6):582-586,5.基金项目
国家自然科学基金(81570381) （81570381）
