中国肺癌杂志2018，Vol.21Issue(1)：1-7,7.DOI:10.3779/j.issn.1009-3419.2018.01.01
胸腺瘤合并重症肌无力患者预后的临床研究
Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis
袁东风 1谷志涛 2梁光辉 1方文涛 2李印 1中国胸腺肿瘤研究协作组3
作者信息
- 1. 450008 郑州,郑州大学附属肿瘤医院胸外科
- 2. 200030 上海,上海交通大学附属上海胸科医院
- 折叠
摘要
Abstract
Background and objective Thymoma is frequently associated with myasthenia gravis (MG). However,whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. Methods A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way. Results Thymic tumor tissue type credit has correlation with MG,difference was statistically significant (χ2=24.908, P<0.001). MG: incidence of B2 type (58/178, 32.58％) > B3 type (65/239,27.20％) > B1 (27/132, 20.45％) > AB (43/267, 16.10％) > type A, 10.17％ (6/59), Masaoka stage has no correlation with MG (χ2=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05),and whether the merger MG (χ2=0.113, P=0.736), postoperative adjuvant radiotherapy (χ2=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ2=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ2=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ2=24.695, P<0.001). Conclusion Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.关键词
胸腺瘤/重症肌无力/胸腺扩大切除/预后Key words
Thymoma/Myasthenia gravis/Extended thymectomy/Prognosis引用本文复制引用
袁东风,谷志涛,梁光辉,方文涛,李印,中国胸腺肿瘤研究协作组..胸腺瘤合并重症肌无力患者预后的临床研究[J].中国肺癌杂志,2018,21(1):1-7,7.
