中国肺癌杂志2018，Vol.21Issue(1)：8-15,8.DOI:10.3779/j.issn.1009-3419.2018.01.02
肺叶与亚肺叶切除治疗60岁以上Ia期小细胞肺癌的预后比较分析
Prognostic Analysis of Lobectomy versus Sublobar Resection in Patients Aged ≥60Years with Stage Ia Small Cell Lung Cancer
曾海康 1刘洋 1夏晓君 1李谨 2何建行1
作者信息
- 1. 510120 广州,广州医科大学附属第一医院胸外科
- 2. 510120 广州,广州医科大学附属第一医院呼吸疾病国家重点实验室
- 折叠
摘要
Abstract
Background and objective Currently, the prognosis of lobectomy and sub-lobectomy for the treatment of stage Ia small cell lung cancer (SCLC) is rarely reported. We retrospectively studied T1N0M0 (≤3 cm) SCLC patients aged ≥60 years, aiming to comparatively analyze the prognosis of lobectomy and sub-lobectomy in treating patients with Ia SCLC.Methods Patients with stage Ia SCLC diagnosed by pathologic between 1992 and 2010 were selected from the "Surveillance,Epidemiology and End Results database"(SEER). Outcome data were compared using Kaplan-Meier (Log-rank test) and Cox model multivariate analysis. Results We identified 515 patients. Median overall survival (OS) of the lobectomy (n=110), sublobar resection (n=57) and non-surgical (n=348) cohort were 45, 23 and 16 months, respectively. The corresponding 5-year OS of the three groups were 44％, 30％, and 14％, respectively. No significant difference in the prognosis of patients with or without lymph node examination/ dissection (P=0.107) and the 5-year OS of patients underwent lobectomy with chemoradiation was 50％. Cox multivariable analysis showed that operation treatment, including lobectomy and sublobectomy, was one of the independent factors associated with the prognosis of early SCLC patients, and patients undergo lobectomy shows a better OS compared with sublobar resection (Lob vs Sub, HR=0.645; 95％CI: 0.433-0.961, P=0.031). Conclusion For age ≥60 years T1N0M0 (≤3 cm) SCLC patients, we recommend anatomical lobectomy combined with adjuvant chemoradiation.关键词
小细胞肺癌/亚肺叶切除/肺叶切除/放化疗/预后Key words
SCLC/Sub-lobectomy/Lobectomy/Radiochemotherapy/Prognosis引用本文复制引用
曾海康,刘洋,夏晓君,李谨,何建行..肺叶与亚肺叶切除治疗60岁以上Ia期小细胞肺癌的预后比较分析[J].中国肺癌杂志,2018,21(1):8-15,8.
