中国肺癌杂志2018，Vol.21Issue(1)：43-49,7.DOI:10.3779/j.issn.1009-3419.2018.01.06
非小细胞肺癌相关lncRNA的研究进展
Progress of Long Non-coding RNA in Non-small Cell Lung Cancer
摘要
Abstract
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity.It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation,differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therpy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurence, diagnosis, therpy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.关键词
长链非编码RNA/肺肿瘤/诊断/治疗/预后Key words
LncRNA/Lung neoplasms/Diagnosis/Treatment/Prognosis引用本文复制引用
张亚琛,梁迪,靳晶,刘聪敏,贺宇彤..非小细胞肺癌相关lncRNA的研究进展[J].中国肺癌杂志,2018,21(1):43-49,7.基金项目
本文受2017年河北省医学科学研究重点课题计划(No.20170765, No.20170159)项目资助This paper was supported by the grants from the Medical Scientific Research Key Project for 2017 in Hebei Province (to Yutong HE)(No.20170159) and (to Di LIANG)(No. 20170765). （No.20170765, No.20170159）
