中国肺癌杂志2018，Vol.21Issue(1)：50-56,7.DOI:10.3779/j.issn.1009-3419.2018.01.07
环状RNA在肺癌研究中的进展
Circular RNA in Lung Cancer Research: Biogenesis, Functions and Roles
摘要
Abstract
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death in China. In recent years, therapies for oncogenedrivers and immune checkpoints have proved inspiring. Circular RNA (circRNA), which is a kind of RNA with covalent ring structure relating to stages and metastasis of cancer, has many special biological functions in physiological processes, diseases and so on. Thus, circRNA is expected to be a potential biomarker for cancer prediction and treatment in view of its high conservation and tissue-specific. However, function analysis and regulatory mechanism of circRNA in lung cancer come so far remains unclear and limited literatures are available. In this review, we highlight the research history, formation mechanism, biological function of circRNA and research progress in cancer, especially in lung cancer. We mean to provide theoretical evidences and new ideas for researches on circRNAs in lung cancer.关键词
环状RNA/非编码RNA/MicroRNA海绵/竞争性内源RNA/肿瘤Key words
Circular RNA/Non-coding RNA/MicroRNA sponge/ceRNA/Cancer引用本文复制引用
成星宇,申洪..环状RNA在肺癌研究中的进展[J].中国肺癌杂志,2018,21(1):50-56,7.基金项目
本研究受广东省科技计划项目(No.2010B060300001)资助This paper was supported by the grant from Science and Technology Planning Project of Guangdong Province, China (to Hong SHEN)(No.2010B060300001). （No.2010B060300001）
