中国肺癌杂志2018，Vol.21Issue(1)：57-62,6.DOI:10.3779/j.issn.1009-3419.2018.01.08
肺癌干细胞作为靶点的肺癌治疗策略研究进展
Research Progress in the Therapeutic Strategy Based on Targeting at Lung Cancer Stem Cell
摘要
Abstract
With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and heterogeneity of lung cancer. Tumor recurrence, metastasis and drug resistance of lung cancers could be clarified by LCSC hypothesis. Thus it's therapeutically prospective to target at these cells. This review summarizes the biomarkers of LCSCs and their aberrant signal pathways, as well as the therapeutic strategies targeting at LCSCs.关键词
肺癌/肺癌干细胞/分子靶向治疗/肿瘤干细胞Key words
Lung neoplasms/Lung cancer stem cells/Molecular targeted therapy/Neoplastic stem cells引用本文复制引用
赖红锦,林锋,陈楠,文舒,胡晓,刘伦旭..肺癌干细胞作为靶点的肺癌治疗策略研究进展[J].中国肺癌杂志,2018,21(1):57-62,6.基金项目
本文受贵州省科技厅科研基金(No.黔科合区域合[2014]7004)资助 （No.黔科合区域合[2014]7004）
This study was supported by the grant from Science and Technology Department of Guizhou Province (to Lunxu LIU)( No.[2014]7004). （to Lunxu LIU）
