中国感染控制杂志2017，Vol.16Issue(11)：1016-1020,5.DOI:10.3969/j.issn.1671-9638.2017.11.006
NICU鲍曼不动杆菌的医院感染与耐药性分析
Healthcare-associated infection and drug resistance of Acinetobacter baumannii in neonatal intensive care units
摘要
Abstract
Objective To investigate the clinical characteristics and antimicrobial resistance of Acinetobacter baumannii(A.baumannii) in neonatal intensive care units (NICUs).Methods The clinical isolation and antimicrobial resistance of A.baumannii causing healthcare-associated infection(HAD in 4 NICUs of a hospital from October 2012 to October 2014 were analyzed statistically.Results A total of 11 640 neonates were admitted in 4 NICUs,500(4.3 ％) developed HAI,51 (10.2 ％) developed 52 cases of A.baumannii infection.Distribution of A.baumannii infection was as follows:NICU of extremely premature infants,premature infants,full-term infants,and surgical NICU were 42,1,4,and 5 cases respectively.Incidences of A.baumannii HAI in 4 seasons were compared,difference was statistically significant(x2 =16.05,P＜0.05),infection mainly occurred in the spring and summer.A.baumannii had high resistance rates to β-1actam antibiotics (such as piperacillin/sulbactam,cefepime,imipenem)and gentamycin(＞90 ％),resistance rate to amikacin was the lowest (51.9 ％).Among 52 strains of A.baumannii,46 were multidrug-resistant strains,and 3 were extensively drug-resistant strains.Conclusion A.baumannii HAI is most serious in NICU of extremely premature infants,resistance rates to commonly used antimicrobial agents are high.关键词
新生儿重症监护病房/鲍曼不动杆菌/医院感染/耐药性Key words
neonatal intensive care unit/Acinetobacter baumannii/healthcare-associated infection/drug resistance分类
医药卫生引用本文复制引用
庄璐,章晟,宋婕,张玉佩,韦秀娟,夏娴,卢庆彬,李秋平,封志纯..NICU鲍曼不动杆菌的医院感染与耐药性分析[J].中国感染控制杂志,2017,16(11):1016-1020,5.基金项目
国家自然科学基金(81170602) （81170602）
中国博士后科学基金(2013M542472) （2013M542472）
