中国感染控制杂志2017，Vol.16Issue(11)：1069-1073,5.DOI:10.3969/j.issn.1671-9638.2017.11.018
手足口病住院患儿的病原学和临床特征
Pathogenic and clinical characteristics of hospitalized children with hand-foot-and-mouth disease
周喜桃 1肖鹏程 1曾莉怡 1龙云铸 1吕霞 1肖飞跃1
作者信息
摘要
Abstract
Objective To understand the pathogenic distribution and epidemiological trend of hand-foot-and-mouth disease (HFMD),and provide evidence for the prevention and control of HFMD.Methods Children who were diagnosed with HFMD in a hospital between January and December 2015 were investigated,real time fluorescence PCR was used to detect enterovirus universal type EV,enterovirus 71 (EV71),and Coxsackievirus A16 (CoxA16) in specimens from children with HFMD.Positive rates and distribution of various types of EV among children of different months,genders,age groups,and infection types were analyzed.Results A total of 837 throat swab specimens from HFMD children were collected in 2015,380 (45.40％) of which were EV positive specimens.Virus typing showed that 110 (28.95 ％),7 (1.84 ％),6(1.58 ％),and 257(67.63 ％) were positive specimens for EV71,CoxA16,EV71 + CoxA16,and other types of EV.HFMD had a high prevalence since April,reached a peak in May-June,and remained high incidence in July-December.Positive rates of EV in children of different months were statistically different (P＜0.05).The age of onset was mainly in children under 3 years.Positive rates of EV and constitute ratios of different types of EV in children of different age groups were all statistically different (all P＜0.05).The positive rate of EV in severe HFMD cases was higher than common cases (65.34％ vs 27.06％,P＜0.001).The proportion of severe cases in children with EV71 infection and other types of EV infection were 90.00％ and 60.70％ respectively;children with EV71 + CoxA16 double infection were all severe cases.Constitute of EV types in children with different infection types was statistically different(P＜0.001).Conclusion In 2015,EV infection in hospitalized children with HFMD in this hospital was mainly caused by other types of EV (nonEV71 and non-CoxA16),the high prevalence season,high-risk population under 3 years of age,and severe cases should be paid high attention,prevention and treatment should be performed well.关键词
手足口病/荧光PCR/肠道病毒Key words
hand-foot-and-mouth disease/fluorescence PCR/enterovirus分类
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周喜桃,肖鹏程,曾莉怡,龙云铸,吕霞,肖飞跃..手足口病住院患儿的病原学和临床特征[J].中国感染控制杂志,2017,16(11):1069-1073,5.
