中国康复2017，Vol.32Issue(6)：484-487,4.DOI:10.3870/zgkf.2017.06.013
三七皂苷对运动性贫血大鼠海马BDNF表达的影响
Effects of PNS on the Hippocampal BDNF expression in sports anemia rats
摘要
Abstract
Objective:To investigate the effects of sports anemia on the expression of BDNF in rat hippocampi and the roles of PNS in rat nervous system in the sports anemia development.Methods:Twenty-four healthy male 4-week-old SD rats were randomly divided into control group,sports group and PNS intervention group.The rats in both sports group and PNS intervention group were subjected to the increasing load treadmill exercise for 10 weeks,and those in the PNS intervention group were given drug intervention from the fifth week additionally.Hippocampal BDNF mRNA gene expression was detected using real time PCR,and BDNF protein content was determined by ELISA.Results:After ten weeks increasing load treadmill training,the hippocampal BDNF mRNA and protein expression in sports group was significantly lower than in control group and PNS intervention group (P＜0.05).Both BDNF mRNA and protein expression showed no significant difference between PNS intervention group and control group.Conclusion:These results suggest that sports anemia may induce brain hypoxic-ischemic injury in rats.The PNS can promote the expression of BDNF in rat hippocampi,which may play a protective role in sports anemia-induced brain hypoxic-ischemic injury.关键词
运动性贫血/三七皂苷/海马/BDNFKey words
sports anemia/PNS/Hippocampal/BDNF分类
医药卫生引用本文复制引用
缪吉,雷涛,杨光显,金丽..三七皂苷对运动性贫血大鼠海马BDNF表达的影响[J].中国康复,2017,32(6):484-487,4.基金项目
霍英东教育基金会青年教师基金基础性研究项目(121103) （121103）
