中国康复理论与实践2018，Vol.24Issue(1)：29-36,8.DOI:10.3969/j.issn.1006-9771.2018.01.006
昼夜节律紊乱对大鼠运动耐力、运动后血压和心率的影响
Influence of Circadian Rhythm Disruptions on Exercise Endurance, Blood Pressure and Heart Rate after Exercise in Rats
摘要
Abstract
Objective To observe the influence of circadian rhythm disruptions on exercise capability in rats. Methods A total of 30 spontaneously hypertensive rats (SHR) and age and weight matched homologous normal blood pressure WKY rats were randomly divided into normal circadian rhythm group (control group), twelve hours cir-cadian rhythm disruption group (observation group 1), six hours circadian rhythm disruption group (observation group 2). Each group included ten SHR rats and WKY rats, changing the light/dark time to construct circadian rhythm disruption model. Exercise endurance, blood pressure and heart rate after exhaustion were measured be-fore and one, two and three months after modeling. Results The interaction of time and circadian rhythm was significant on the exhaustion time of SHR rats (F=2.409, P=0.047). After three months of modeling, the exhaustion time of the control group was more than that of the obser-vation groups 1 and 2 (F=4.290, P=0.032). The interaction of time and circadian rhythm was not significant on the exhaustion time of WKY rats (F=0.717, P=0.638), there was no significant difference in the exhaustion time among groups (P>0.05). For SHR rats, after three months of modeling, the systolic pressure, diastolic pressure and mean arterial pressure after exhaustion of the observation group 1 were higher than those of the control group and the observation group 2 (P<0.05), the heart rate of the observation groups 1 and 2 was higher than that of the control group (P<0.05). But there was no significant difference in the systolic pressure, diastolic pressure, average arterial pressure and heart rate of WKY rats among groups (P>0.05). Conclusion Circadian rhythm disruptions can reduce the exercise endurance of SHR rats, which may be related to the cardiovascular function impairment.关键词
高血压/昼夜节律紊乱/运动耐力/血压/心率/大鼠Key words
hypertension/circadian rhythm disruptions/exercise endurance/blood pressure/heart rate/rats分类
医药卫生引用本文复制引用
李一,王文竹,张玉阁,申嘉怡,张通..昼夜节律紊乱对大鼠运动耐力、运动后血压和心率的影响[J].中国康复理论与实践,2018,24(1):29-36,8.基金项目
1.中央级公益性科研院所基本科研业务费专项资金项目(No. 2017CZ-1) （No. 2017CZ-1）
2.中国康复研究中心基金课题(No. 2017ZX-4 （）
No. 2017ZX-10) Supported by Special Fund Project for Basic Scientific Research Business of Central Public Scientific Research Insti-tute (No. 2017CZ-1) and China Rehabilitation Research Center Project (No. 2017ZX-4 （No. 2017CZ-1）
No. 2017ZX-10) （）
