中国输血杂志2017，Vol.30Issue(11)：1251-1253,3.DOI:10.13303/j.cjbt.issn.1004-549x.2017.11.011
多次单采血小板献血者血清可溶性转铁蛋白受体和血清铁蛋白的变化
Change analysis of soluble Transferrin receptor and serum ferritin in blood donors with multiple platelet apheresis
摘要
Abstract
Objective To explore the change of reserve ferrum of in blood donors with multiple platelet apheresis.Methods 99 donors (84 males and 15 females) who donated platelets for equal or more than 16 times and 29U were selected as the experimental group.100 whole blood donors (86 males and 14 females) were randomly selected as the control group.The soluble transferrin receptor (sTfR) and serum ferritin (SF) levels were measured.The results in the two groups were analyzed with double factor analysis of variance.Statistical classification was performed based on platelet apheresis duration and gender.Results sTfR(mg/L):Male and female platelet donors and the control group presented concentrations of respectively 2.877± 1.245 vs 2.614±0.706 and 3.029±0.908 vs 2.453±0.769(P＜0.05).The donors who donated platelets for 50-100 times and 0 time were measured at 3.031± 1.361 vs 2.591±0.713,respectively(P＜0.01).SF(ng/mL):Male and female platelet donors and the control group presented concentrations 45.89±35.67 vs 105.35±91.6and 29.40±24.19 vs 91.32±68.97,respectively(P＜0.01).The donors who donated platelets 16-50 times,50-100 times and ≥ 101 time were measured at 42.41±3.90,41.99±34.84,47.23±35.68,respectively.Donors who never donated platelets were measured at 103.39±88.65 (P＜0.01).Effect of gender on sTfR and SF was minor(P＞0.05).Conclusion Multiple platelet apheresis may result in decreased SF and increased sTfR.This,however,is still within the reference range.Our study indicates that it is safe to donate platelets many times.That being said,we need to pay closer attention to the issue and try to minimize potential threats.关键词
单采血小板/血小板捐献者/可溶性转铁蛋白受体/血清铁蛋白/体内储存铁Key words
apheresis platelets/platelets donors/soluble transferring receptor/serum ferritin/reserve ferrum分类
医药卫生引用本文复制引用
葛健民,赵宏祥,黄宏亮,袁秀珍,任素玲..多次单采血小板献血者血清可溶性转铁蛋白受体和血清铁蛋白的变化[J].中国输血杂志,2017,30(11):1251-1253,3.基金项目
2015年江苏省采供血行业开放性科研课题(JSCGX20150) （JSCGX20150）
