中国输血杂志2017，Vol.30Issue(11)：1265-1267,3.DOI:10.13303/j.cjbt.issn.1004-549x.2017.11.015
血小板抗体检测在新生儿血小板减少症诊治中的应用
The application of platelet antibody tests in the diagnosis and treatment of neonatal thrombocytopenia
邵智利 1马德冉 1韩利霞 1王乐 1陈静 2刘景汉3
作者信息
- 1. 河北省儿童医院输血科
- 2. 河北石家庄050031
- 3. 河北医科大学附属第三医院
- 折叠
摘要
Abstract
Objective To evaluate the application of platelet antibody tests in the diagnosis and treatment of neonatal thrombocytopenia.Methods The monoclonal antibody solid phase platelet antibody test (MASPAT)was applied to detect platelet antibodies in samples acquired from 18 mothers and 110 infants suffering from thrombocytopenia who received treatment in our hospital during May 2014 to October 2016.According the test results,samples were divided into the platelet antibody-positive group (observation group) and the platelet antibody negative group (control group).We compared the condition occurrence time line and the intracranial hemorrhage status between the two groups.The 24h corrected count increment (CCI) was also compared.Results The positive rate of platelet antibody presence in the observation group was 20.91％ (23/110).The rates of thrombocytopenia occurrence time points ≤72 h in the observation group and the control group were 82.61％ (19/23) vs 49.43％ (43/87) (P＜0.05) while the rates of an occurrence time point beyond 72 hours were 17.39％ (4/23)) vs 50.57(44/87) (P＜0.05);The intracranial hemorrhage rates were 60.87％ (14/23) vs 31.03％ (27/87) (P ＜0.05).34 severe thrombocytopenia cases with platelet count＜50 x 109/L were processed with random transfusion followed by 24h CCI measurement,which yielded no statistically significant difference between the two groups (P＞0.05).Rates of cases with CCI ≥ 7.5 in the two groups were 100％ (7/7) vs 85.19％ (23/27),respectively.Conclusion Most infants with autoimmune NT (neonate thrombocytopenia) mostly suffer from acute onset of symptoms and severe intracranial hemorrhage.Infants with a low platelet count due to immune issues can receive random transfusion and the results lived to our expectations.For pregnant women,immune platelet antibody monitoring during pregnancy could help reducing the occurrence of neonatal thrombocytopenia.关键词
血小板抗体/新生儿血小板减少症/固相凝集/血小板计数/血小板输注Key words
platelet antibody/neonatal thrombocytopenia/MASPAT/platelet count/platelet transfusion分类
医药卫生引用本文复制引用
邵智利,马德冉,韩利霞,王乐,陈静,刘景汉..血小板抗体检测在新生儿血小板减少症诊治中的应用[J].中国输血杂志,2017,30(11):1265-1267,3.
