中国现代医学杂志2017，Vol.27Issue(25)：32-36,5.DOI:10.3969/j.issn.1005-8982.2017.25.007
硝夫太尔制霉素和甲硝唑栓对妊娠合并细菌性阴道病患者绒毛超微结构及Caspase-3表达的影响
Effect of Nifuratel nystatin and Metronidazole suppositories on villus ultrastructure and caspase-3 expression of pregnant women with bacterial vaginosis
张琼 1胡静 1罗春叶1
作者信息
- 1. 云南省第二人民医院生殖医学科,云南昆明650021
- 折叠
摘要
Abstract
Objective To investigate the effect of Nifuratel nystatin and Metronidazole suppositories on villus ultrastructure and adverse pregnancy outcomes in pregnant women with bacterial vaginosis.Methods The pregnant women with bacterial vaginosis who were admitted to our hospital from April 2013 to July 2015 were divided into group A (37 cases without medication),group B (62 cases treated with Nifuratel nystatin) and group C (60 cases treated with Metronidazole suppositories);at the same time 60 normal pregnant women were enrolled into group D (normal group).The treatment effect was compared between the groups B and C.The adverse pregnancy outcomes,villus ultrastructure and expression of apoptosis protein caspase-3 were compared among the four groups.Results There was no significant difference in the total effective rate or incidence of side effects between the groups B and C (P＞ 0.05),but the recurrence rate in the group B (1.61％) was lower than that in the group C (18.33％,P＜ 0.05).The incidences of adverse pregnancy outcomes in the groups B,C and D were lower than that in the group A (P ＜ 0.05).There were significant differences in the villous ultrastructure and caspase-3 expression among the groups A,B and C (P ＜ 0.05).Conclusions Nifuratel nystatin has high efficiency and a low recurrence rate in the treatment of bacterial vaginosis in pregnant women,and helps to avoid further damage to villus structure and the occurrence of apoptosis.关键词
硝夫太尔制霉素/甲硝唑/细菌性阴道病/妊娠Key words
Nifuratel nystatin/Metronidazole/bacterial vaginosis/pregnancy分类
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张琼,胡静,罗春叶..硝夫太尔制霉素和甲硝唑栓对妊娠合并细菌性阴道病患者绒毛超微结构及Caspase-3表达的影响[J].中国现代医学杂志,2017,27(25):32-36,5.
