中国现代医学杂志2017，Vol.27Issue(25)：115-118,4.DOI:10.3969/j.issn.1005-8982.2017.25.024
N-末端脑钠肽前体联合超声心动图对急性肺栓塞患者预后的评估
Value of N-terminal pro-B-type natriuretic peptide combined with echocardiogram in evaluation of prognosis in patients with acute pulmonary embolism
徐慧 1李媛媛 1毛毅敏2
作者信息
- 1. 南阳医学高等专科学校第一附属医院呼吸内科,河南南阳473058
- 2. 河南科技大学第一附属医院呼吸内科,河南洛阳471003
- 折叠
摘要
Abstract
Objective To explore the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) combined with echocardiogram in the evaluation of prognosis in patients with acute pulmonary embolism (APE).Methods One hundred and thirty-five patients with APE admitted to the First Affiliated Hospital of Henan University of Science and Technology from 2010 to 2014 were retrospectively analyzed.All APE patients were divided into normal right ventricular function group (71 cases) and right ventricular dysfunction group (64 cases) according to echocardiographic results,and into favorable prognosis group (81 cases) and poor prognosis group (54 cases) according to whether there was occurrence of main adverse events.The NT-proBNP and other clinical indexes were analyzed statistically to obtain the factors influencing the prognosis of APE patients.Results The rates of adverse events and death in the right ventricular dysfunction group were higher than those in the normal right ventricular function group (P ＜ 0.05).Compared with the normal group,the levels of NT-proBNP,cTnI and PaO2 in the right ventricular dysfunction group increased (P ＜ 0.05).The levels of NT-proBNP and cTnI in the poor prognosis group were higher than those in the favorable prognosis group (P ＜ 0.05).Logistic regression analysis showed that right ventricular dysfunction,NT-proBNP,cTnI and history of deep vein thrombosis were related to poor prognosis of inhospital patients (OR =8.503,5.474,5.418 and 5.084 respectively).Conlusions NT-proBNP and right ventricular dysfunction are positively correlated,both are the independent predictors of prognosis of APE patients,and the combination of the two has greater value in assessment of patients' prognosis.关键词
急性肺栓塞/N-末端脑钠肽前体/右心功能不全Key words
acute pulmonary embolism/N-terminal Pro-brain natriuretic peptide/right ventricular dysfunction分类
医药卫生引用本文复制引用
徐慧,李媛媛,毛毅敏..N-末端脑钠肽前体联合超声心动图对急性肺栓塞患者预后的评估[J].中国现代医学杂志,2017,27(25):115-118,4.
