中国现代医学杂志2017，Vol.27Issue(26)：1-6,6.DOI:10.3969/j.issn.1005-8982.2017.26.001
银杏叶提取物对COPD大鼠肺组织超微结构的影响
Effect of Ginkgo biloba extract on pulmonary ultrastructures of rats with chronic obstructive pulmonary disease
摘要
Abstract
Objective To study the intervention effect of Ginkgo biloba extract (GBE) on the pulmonary ultrastructural changes in rats with chronic obstructive pulmonary disease (COPD).Methods Ninety Wistar rats were randomly divided into normal control group (group A),COPD control group (group B),early-stage GBE treatment group (group C),late-stage GBE treatment group (group D),Erythromycin early-treatment group (group E),and Erythromycin late-stage treatment group (group F).Six rats were randomly seleted from each group,ultrastructural changes of the lungs were observed by transmission electron microscopy,and the rates of pathological changes of mitochondria were calculated.Results The groups B,C,D,E and F all showed characteristic pathological changes of COPD to different extent.Under the transmission electron microscope,the ultrastructures in the groups C,D,E and F were more complete than those in the group B,and the rates of mitochondrial lesions were conspicuously lowered in the treatment groups,suggesting that GBE had a positive therapeutic effect.Conclusions GBE has inhibitory effects on airway and vascular remodeling in rat model of COPD.关键词
慢性阻塞性肺疾病/银杏叶提取物/超微结构/线粒体病变率Key words
chronic obstructive pulmonary disease/Ginkgo biloba extract/ultrastructure/rate of mitochondrial lesion分类
医药卫生引用本文复制引用
潘玲,邓祯,谭玉萍,杨红梅,杨益宝,梁炜,李瑞祥..银杏叶提取物对COPD大鼠肺组织超微结构的影响[J].中国现代医学杂志,2017,27(26):1-6,6.基金项目
国家自然科学基金(No:81260005) （No:81260005）
