中国现代医学杂志2017，Vol.27Issue(26)：52-55,4.DOI:10.3969/j.issn.1005-8982.2017.26.010
钙网织蛋白在类风湿关节炎早期诊断及活动度评估中的作用
Role of calreticulin in early diagnosis and activity assessment of rheumatoid arthritis
摘要
Abstract
Objective To investigate the role of calreticulin (CRT) in the diagnosis and assessment of disease activity in the patients with early rheumatoid arthritis (RA).Methods Serum CRT level was measured by ELISA in 45 patients with early RA,35 cases with osteoarthritis (OA) and 30 healthy controls (HC).ESR was measured by the Westergren method.Serum CRP level was measured by immunonephelometry.The correlations of CRT with Disease Activity Score for 28 joints (DAS28 score),ESR and CRP were assessed by Spearman's rank correlation coefficient.Results The serum concentration of CRT of the early RA patients [(6.7 ± 2.5) μg/L] was higher than that of the OA patients and HC [(3.9 ± 0.9) and (3.8 ± 0.7) μg/L,P ＜ 0.05],while there was no significant difference between the OA and HC groups (P＞ 0.05).Compared with the OA and HC groups,the ESR and CRP levels were elevated in the early RA group (P ＜ 0.05).Serum CRT concentration in the early RA patients was positively correlated with DAS28 score,ESR and CRP (rs=0.391,0.459 and 0.454;P=0.008,0.002 and 0.002).Conclusions Together with ESR and CRP,CRT may be used as a potential biomarker for early diagnosis of RA and for assessment of disease activity.关键词
类风湿关节炎/钙网织蛋白/疾病活动度/DAS28评分Key words
rheumatoid arthritis/calreticulin/disease activity/DAS28 score分类
医药卫生引用本文复制引用
丁红梅,刘建华,郑芳,贾曙光,魏蔚,孙晓东,赵雁艳,孟海妹..钙网织蛋白在类风湿关节炎早期诊断及活动度评估中的作用[J].中国现代医学杂志,2017,27(26):52-55,4.基金项目
河北省科技计划项目(No:152777157) （No:152777157）
