中国现代医学杂志2017，Vol.27Issue(26)：56-60,5.DOI:10.3969/j.issn.1005-8982.2017.26.011
转铁蛋白的结构功能和潜在临床应用价值
Structural function and potential clinical value of transferrin
摘要
Abstract
Iron is necessary for all living organisms to maintain cell growth,reproduction and metabolic activity.The majority of free iron in the body is transported by transferrin.Transferrin is a [3-globulin which is responsible for binding and carrying iron in the plasma.The primary role of transferrin is to transport iron from the digestive tract and erythrocyte safely around the body to supply growing cells.The metal ion-binding sites of transferrin include two tyrosines,one aspartic acid and one histidine residue.Furthermore,transferrin,as a class of multi-functional protein,not only transports Fe2+,but also has many physiological and biochemical functions,such as antimicrobial activity,promoting cell growth and cell protection.In addition,as a new type of drug targeting carrier,transferrin has broad application prospects in the field of tumor targeted therapy.In this review,we discussed transferrin in terms of structural characteristics,diversity,biological functions and clinical application.关键词
转铁蛋白/转铁蛋白受体/结构/临床应用/靶向治疗Key words
transferrin/transferrin receptor/structure/clinical application/targeted therapy分类
医药卫生引用本文复制引用
彭健,张耀婷,陈杰,丁成明,李慧,张礼铭,夏赞贤..转铁蛋白的结构功能和潜在临床应用价值[J].中国现代医学杂志,2017,27(26):56-60,5.基金项目
国家自然科学基金(No:U1603126) （No:U1603126）
湖南省自然科学基金(No:2017JJ2334) （No:2017JJ2334）
