中国现代医学杂志2017，Vol.27Issue(26)：70-74,5.DOI:10.3969/j.issn.1005-8982.2017.26.014
94例肢端肥大症住院患者的临床病理及疗效分析
Analysis of clinicopathological characteristics and therapeutic effect in 94 hospitalized patients with acromegaly
摘要
Abstract
Objective To collate clinical data of 94 hospitalized patients with acromegaly,explore the diagnostic accuracy and the therapeutic effect,and clarify the clinical features.Methods This retrospective study was analyzed using SPSS 22 software.Results In the 94 patients,31 were males (33.0％) and 63 were females (67.0％).The age at diagnosis ranged from 14 to 72 years with the largest proportion of 41-50 years (35.1％).Among the initial symptoms,changes of appearance or limbs occurred in 78 patients (83.0％),headache in 43 patients (45.7％),vision loss or visual field defect in 41 patients (43.6％),amenorrhea or lactation in 11 patients (11.7％),and sterility or sexual dysfunction in 2 patients (2.1％).In the aspect of imaging examinations,10 patients were diagnosed with CT (10.6％) and 84 patients with MRI (89.4％).There were 66 imaging results with clear description of tumor size (displayed as the maximal tumor diameter),macroadenomas and giant adenomas of pituitary gland accounted for 93.94％ and microadenomas accounted for 6.06％.Serum GH level was positively correlated to tumor size.There were 93 patients treated with surgery,the serum GH level was lowered after operation except the patients with microadenomas.After surgery,90patients accepted immunohistochemical examination,in which 94.45％ had GH positive expression.The receiver operating characteristic curve showed preoperative serum GH level was not correlated with postoperative immunohistochemical results of GH expression.Conclusions Among the 94 patients,women were more than men,their age range at diagnosis concentrated in 31-60 years.The primary initial symptoms were changes of appearance or limbs,headache,vision loss or visual field defect.Macroadenomas and huge adenomas were the majority.Serum GH level was positively correlated with tumor size and could be reduced after surgery.Immunohistochemical expression of GH was not completely in accordance with preoperative serum level of GH.The diagnostic accuracy of GH level to GH expression of immunohistochemical results was low.关键词
肢端肥大症/生长激素/垂体腺瘤Key words
acromegaly/growth hormone/pituitary adenoma分类
医药卫生引用本文复制引用
韩闻卿,郑丽宏,姜雅秋..94例肢端肥大症住院患者的临床病理及疗效分析[J].中国现代医学杂志,2017,27(26):70-74,5.基金项目
辽宁省科技厅计划(No:2012225021) （No:2012225021）
