中国现代医学杂志2017，Vol.27Issue(26)：87-91,5.DOI:10.3969/j.issn.1005-8982.2017.26.018
不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响
Effects of different anesthesia methods on perioperative T lymphocyte subsets and IL-2 level in ovarian cancer patients
王必铭 1郑翔1
作者信息
- 1. 浙江省临海市第一人民医院麻醉科,浙江临海317000
- 折叠
摘要
Abstract
Objective To investigate the effect of different anesthesia methods on perioperative T lymphocyte subsets and IL-2 level in ovarian cancer patients.Methods A total of 160 patients with ovarian cancer who underwent radical surgery in our hospital from January 2013 to December 2016 were selected as the subjects and divided into general anesthesia group and epidural anesthesia group according to the random number method,each group had 80 cases.The levels of peripheral blood T lymphocyte subsets and IL-2 were measured in the two groups.Results There was no significant difference in age,body weight,operation time,intraoperative blood loss or infusion volume between the general anesthesia group and the epidural anesthesia group (P＞ 0.05).The levels of CD3+,CD4+ and CD4+/CD8+ were different at different time points (P＜0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in the general anesthesia group were lower than those in the epidural anesthesia group (P ＜ 0.05).The change trends of CD3+,CD4+ and CD4+/CD8+ in the general anesthesia group and the epidural anesthesia group were different (P＜ 0.05).There were differences in the IL-2 levels at different time points (P＜ 0.05).The level of IL-2 in the general anesthesia group was lower than that in the epidural anesthesia group (P ＜ 0.05).There was significant difference in the change of IL-2between the general anesthesia group and the epidural anesthesia group (P ＜ 0.05).Conclusions Epidural anesthesia has less inhibitory effect on perioperative cellular immune function in patients with ovarian cancer radical surgery.关键词
全身麻醉/硬膜外麻醉/卵巢癌/细胞免疫Key words
general anesthesia/epidural anesthesia/ovarian cancer/cellular immunity分类
医药卫生引用本文复制引用
王必铭,郑翔..不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响[J].中国现代医学杂志,2017,27(26):87-91,5.
