中国现代医学杂志2018，Vol.28Issue(3)：28-34,7.DOI:10.3969/j.issn.1005-8982.2018.03.006
HOX转录反义RNA表达对胸腔镜食管癌切除术后风险的预测价值研究
HOX Transcription Antisense RNA as prognostic biomarker in Patients with Thoracoscopic Esophageal Carcinoma
靳超 1郎保平 1张晓1
作者信息
- 1. 郑州大学附属洛阳市中心医院 胸外科,河南 洛阳 471002
- 折叠
摘要
Abstract
Objective To investigate the prognostic value of HOX transcribed antisense RNA expression in patients with thoracoscopic esophagostomy. Methods Totally 92 patients undergoing thoracoscopic esophageal cancer resection were included in this study. Cancer tissue as well as para-cancer normal tissue was collected. RT-PCR was utilized to detect the expression of HOX transcribed antisense RNA. Correlation between HOX transcribed antisense RNA expression and postoperative recurrence as well as survival was analyzed. Results RT-PCR showed that the relative expression of HOTAIR in cancer tissue increased significantly when compared with that in normal tissue [(0.673 ± 0.076) vs (0.387 ± 0.058), P < 0.05]. The area under the curve of HOTAIR for postoperative recurrence was 0.727 (95％ CI: 0.684, 0.884), and that for postoperative survival was 0.769 (95％ CI:0.692, 0.901). At time point of the 3rd year post operation, recurrence rate in group with HOTAIR less than 0.5 was dramatically lower than that of group with HOTAIR > 0.5 group (P < 0.05). Cox model analysis indicated that the degree of differentiation, clinical stage, tumor diameter, lymph node metastasis and HOTAIR were risk factors while postoperative adjuvant radiotherapy and chemotherapy was beneficial for the prognosis of patients. Conclusion HOTAIR is the risk factor for the prognosis of patients experiencing thoracoscopic esophagostomy, which can serve as a prognostic biomarker of esophageal cancer.关键词
食管癌/胸腔镜手术/HOX转录反义RNA/生存率Key words
esophageal carcinoma/thoracoscopic surgery/hox transcriptional antisense rna/survival rate分类
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靳超,郎保平,张晓..HOX转录反义RNA表达对胸腔镜食管癌切除术后风险的预测价值研究[J].中国现代医学杂志,2018,28(3):28-34,7.
