中国现代医学杂志2018，Vol.28Issue(3)：35-40,6.DOI:10.3969/j.issn.1005-8982.2018.03.007
GUCY1A3基因位点rs7692387单核苷酸多态性
与冠状动脉粥样硬化性心脏病的相关性研究
Effect of single nucleotide polymorphisms at rs7692387 site of GUCY1A3 gene on coronary atherosclerotic heart disease
周爽 1尤昕1
作者信息
- 1. 延边大学附属医院检验科,吉林 延吉 133000
- 折叠
摘要
Abstract
Objective To investigate the correlation between single nucleotide polymorphisms at rs7692387 site of GUCY1A3 gene and coronary atherosclerotic heart disease (CAD). Methods Totally 204 patients with CAD (CAD group) and 201 healthy volunteers (control group) from Yanbian Han population of Yanbian University Hospital were involved in this study. SNaPshot technique was utilized to identify single nucleotide polymorphisms at rs7692387 site of GUCY1A3 gene. Statistical analysis was performed for the association between polymorphisms and CAD. Results The genotype frequency at rs7692387 site of GUCY1A3 gene in both groups fitted the Hardy-Weinberg equilibriumin. Frequency of GG genotype in the CAD group was significantly higher than that in the control group (P < 0.05), while frequency of GA + AA genotype in the control group was dramatically higher than that in CAD group (P < 0.05). G and A allele were differently distributed in two groups (P < 0.05). GG genotype at rs7692387 site of GUCY1A3 gene increased risk of CAD (O^^R = 543, 95％ CI = 1.022, 2.327, P = 0.039) while the A allele could reduce the risk of CAD (O^^R = 0.691, 95％ CI = 0.494, 0.968, P = 0.031). Logistic regression analysis plus adjustments for the confounding factors confirmed these results. Conclusion Single nucleotide polymorphisms at rs7692387 site of GUCY1A3 gene is associated with CAD in Yanbian Han population, and GG genotype is potentially detrimental while A allele may be beneficial for occurrence of CAD.关键词
GUCY1A3基因/单核苷酸多态性/冠状动脉粥样硬化性心脏病Key words
GUCY1A3 gene/single nucleotide polymorphism/CAD分类
医药卫生引用本文复制引用
周爽,尤昕..GUCY1A3基因位点rs7692387单核苷酸多态性
与冠状动脉粥样硬化性心脏病的相关性研究[J].中国现代医学杂志,2018,28(3):35-40,6.
