中国现代医学杂志2018，Vol.28Issue(3)：41-45,5.DOI:10.3969/j.issn.1005-8982.2018.03.008
多烯磷脂酰胆碱辅助治疗对妊娠期肝内胆汁淤积症患者免疫功能及SOCS-3、TNF-α、IL-12表达的影响
Effect of polyene phosphatidyl choline on immune function and expression of SOCS-3, TNF-α and IL-12 in patients with intrahepatic cholestasis of pregnancy
周丽华 1杨威2
作者信息
- 1. 江苏医药职业学院,江苏 盐城 224000
- 2. 江苏省盐城市第一人民医院 普外科,江苏 盐城 224006
- 折叠
摘要
Abstract
Objective To investigate the effect of polyene phosphatidylcholine as supplementary therapy on immune function in patients with intrahepatic cholestasis of pregnancy (ICP). Methods A total of 100 patients were included and randomly divided into control group from which patients received standard treatment, and observation group from which patients received treatment of polyene phosphatidylcholine in addition to standard treatment. Levels of ALT, AST, TBA, IL-12, TNF-α and SOCS-3 were measured in all patients. Results No significant difference in all markers between the two groups was observed before any treatments (P > 0.05). After treatment, clinical markers of the disease post-treatment indicated patients being recovered. Levels of Ribaha, TBA, AST and ALT in the observation group were significantly decreased when compared with control group (P < 0.05). Levels of IL-12 and TNF-α were dramatically increased when compared with control group (P < 0.05). Observation group with treatment of polyene phosphatidylcholine experienced significantly higher expression of SOCS-3 while less adverse outcomes when compared with control group (P < 0.05). Conclusion Polyenoic phosphatidylcholine combined with standard treatment effectively improves the outcome of patients with ICP potentially through SOCS-3-mediated inhibition of immune function.关键词
多烯磷脂酰胆碱/妊娠合并胆汁淤积症/细胞因子信号传导负调控因子Key words
polyene phosphatidyl choline/intrahepatic cholestasis of pregnancy/suppressors of cytokine signaling分类
医药卫生引用本文复制引用
周丽华,杨威..多烯磷脂酰胆碱辅助治疗对妊娠期肝内胆汁淤积症患者免疫功能及SOCS-3、TNF-α、IL-12表达的影响[J].中国现代医学杂志,2018,28(3):41-45,5.
