摘要
Abstract
Objective To investigate the therapeutic effect of low molecular heparin plus Tirofiban in acute Deep venous thrombosis (ADVT) and potential underlying mechanisms. Methods Totally 138 cases of ADVT admitted into our hospital from February 2013 to February 2016 were included and randomly divided into control group and observation group (n = 69). Patients from control group received standard treatment of low molecular heparin, while patients from observation group was treated with Tirofiban in addition to low molecular heparin. Limb circumference difference, platelet count, PT, APTT, TT, FIB pre- and post- treatments, PAC-1 and CD62P positive rate were recorded. Results All patients recovered in both groups (P > 0.05). Decrease of limb circumference and FIB concentration in observation group were significant when compared with control group (P < 0.05). Platelet count, PT, APTT and TT were decreased in the two groups while no dramatic difference were founded between the groups (P > 0.05). Positive rate of PAC-1 was decreased significantly with treatment of tirofiban in both observation group and control group when compared with groups receiving low molecular heparin only [(11.45 ± 1.63) ％ vs (7.68 ± 1.03) ％, (11.79 ± 1.67) ％, (3.92 ± 0.94) ％, separately, (P < 0.05)]. Reduction of positive rate of CD62P was more significant with treatment of Tirofiban in both observation group and control group when compared with groups receiving low molecular heparin only [(13.30 ± 1.52) ％ vs (4.83 ± 1.05) ％, (12.89 ± 1.47) ％ vs (9.01 ± 1.26)％, separately, (P < 0.05)]. Conclusion Low molecular heparin combined with Tirofiban is a promising therapeutic option for ADVT, and inhibition of thrombosis is achieved potentially through decreased expression of PAC-1 and CD62P.关键词
低分子肝素/替罗非班/老年/下肢深静脉血栓/血小板激活复合物-1/P选择素Key words
low molecular heparin/Tirofiban/advt/pac-1/cd62p分类
医药卫生
