中国现代医学杂志2018，Vol.28Issue(3)：78-82,5.DOI:10.3969/j.issn.1005-8982.2018.03.016
TLR4及HGF在糖尿病肾病患者中的表达及其与疾病进展的关系
Expression of TLR4 and HGF in patients with diabetic nephropathy and its relationship with disease progression
李晶 1龙建武 2李国娟 1肖志芳 1刘文1
作者信息
- 1. 南华大学附属南华医院内分泌科,湖南 衡阳 421002
- 2. 南华大学附属南华医院普外科,湖南 衡阳 421002
- 折叠
摘要
Abstract
Objective To study the expression of Toll like receptor 4 (TLR4) and hepatocyte growth factor (HGF) in patients with diabetic nephropathy (DN) and its relationship with progression of DN. Methods A total of 72 cases with DN from Sep. 2014 to Sep. 2016 in our hospital were selected as DN group, then divided into high 24 h pro group (n = 31) and low 24 h pro group (n = 41) according to 24 h urinary protein quantitation (24 h pro); anther 20 healthy people in our hospital were selected as the control group. The levels of HGF and the expression of TLR4 in renal tissue were compared between the three groups. Results Compared with the control group, the expression of TLR4 in the renal tissue of DN group was significantly higher (P < 0.01), the expression of TLR4 in the renal tissue of low 24 h pro group was slightly lower than that in high 24 h pro group, but there was no significant difference between the two groups (P > 0.05). Immunohistochemical results showed that TLR4 was negative in the control group, while was overexpressed in DN group, but there was no significant difference between low 24 h pro group and high 24 h pro group (P > 0.05). Compared with the control group, the levels of HGF in serum and urine of DN group were significantly increased, and the levels of HGF in serum and urine of high 24 h pro group was significantly higher than that of low 24 h pro group, respectively; there was significant difference between the two groups (P < 0.05).Conclusion The expression of TLR4 in renal tissue of DN is closely related to the progression of DN; HGF also plays a role in the development and progression of DN.关键词
Toll样受体4/肝细胞生长因子/糖尿病肾病/24h尿蛋白定量Key words
TLR4/HGF/diabetic nephropathy/24 h urinary protein quantitation分类
医药卫生引用本文复制引用
李晶,龙建武,李国娟,肖志芳,刘文..TLR4及HGF在糖尿病肾病患者中的表达及其与疾病进展的关系[J].中国现代医学杂志,2018,28(3):78-82,5.
