摘要
Abstract
Objective To study the urine iodine level and thyroid function in early pregnant women. Methods A total of 199 early pregnant women were selected. Urine iodine was tested by biochemical colorimetric determination; thyroid stimulating hormone (TSH), three free iodine thyroid former glycine (FT3) and free thyroxine (FT4) were detected by electrochemical luminescence. Results Constituent ratio of deficient urinary iodine group, appropriate urinary iodine group, excess urinary iodine group and overdose urinary iodine group was 59.3％, 21.1％, 9.5％ and 10.1％, respectively. The prevalence of thyroidism, subclinical thyroidism, hyperthyroidism and subclinical hyperthyroidism in different urinary iodide levels were not statistically significant (P > 0.05). Prevalence rate of low thyroid hormone level (low T4 concentration) in iodine excess group was higher, and the difference was statistically significant (χ2 = 11.593, P = 0.009). When the iodine nutrition level was higher than 500 ug/L, urine iodine was positively correlated with serum TSH. The level of FT3 in appropriate urinary iodine group was higher than that in excess urinary iodine group, the difference was statistically significant (P < 0.05). There were no statistically significant differences among deficient urinary iodine group, excess urinary iodine group and overdose urinary iodine group (P > 0.05). There was no statistically significant difference in different groups for FT4 level (F = 2.454,P = 0.064); TSH level in excess urinary iodine group was higher than that of deficient urinary iodine group, appropriate urinary iodine group and excess urinary iodine group, respectively, the difference was statistically significant (P < 0.05). There were no statistically significant differences among deficient urinary iodine group, appropriate urinary iodine group and excess urinary iodine group (P > 0.05). Conclusions Iodine deficiency can be found in vast majority of women in early pregnancy, so appropriate iodine intake should be advocated. The prevalence of abnormal thyroid function is significantly higher in deficient urinary iodine group than that in appropriate urinary iodine group, indicating that women should avoid excessive or deficient iodine in early pregnancy.关键词
孕早期/碘营养/甲状腺功能Key words
early pregnancy/iodine nutrition/thyroid function分类
医药卫生
