中国畜牧杂志2018，Vol.54Issue(1)：38-41,46,5.DOI:10.19556/j.0258-7033.2018-01-038
猪FRZB、ABCF1基因多态性与生长性状的关联分析
Genetic Polymorphism of FRZB Gene and ABCF1 and Their Association with Growth Traits in Pigs
摘要
Abstract
FRZB gene regulates cell growth by inhibiting Wnt signaling pathway,ABCF1 (also known as ABC50:ATP-binding cassette 50) binds to eukaryotic initiation factor 2 (eIF2) and is required for efficient translation initiation,so they can be selected as candidate genes for growth trait.In this study,we detected the genotype of two SNPs in 5'-UTR of FRZB and ABCF1gene by sequencing in pig population and analyzed the effects of the genotype on growth traits.The results showed that the locus ofA-532G ofFRZB gene in American Large White pigs was significantly associated with back fat thickness (P＜0.01),and the body length was closed to significant level (P=0.05).For the locus of 254A/G of ABCF1 gene,there were significantly associated with the back fat thickness,left and right nipple of teat number in American Large White pigs (P＜0.05),and the birth weight in France Large White pigs (P＜0.05).These results suggest that FRZB and ABCF1 may be the major candidate genes for growth traits in pigs.关键词
FRZB/ABCF1/多态性/生长性状/关联分析/猪Key words
FRZB/ABCF11/Polymorphism/Growth traits/Association analysis/Pig分类
农业科技引用本文复制引用
杨华,徐珍,陈佳,姜佳佳,毛翠,毛慧敏,左波,徐在言..猪FRZB、ABCF1基因多态性与生长性状的关联分析[J].中国畜牧杂志,2018,54(1):38-41,46,5.基金项目
国家科技支撑计划资助(2014BAD20B01) （2014BAD20B01）
湖北省农业科技创新中心创新团队资助 （）
浙江省重大科技专项(2014C02010) （2014C02010）
中央高校基本科研业务费专项(2014PY038、2662016PY012) （2014PY038、2662016PY012）
