中国循证儿科杂志2017，Vol.12Issue(6)：429-433,5.DOI:10.3969/j.issn.1673-5501.2017.06.005
早产儿生后补充维生素A可预防支气管肺发育不良:基于6篇随机对照试验的Meta分析
Vitamin A supplementation in the prevention and treatment of bronchopulmonary dysplasia in premature infants:a meta-analysis based on 6 randomized control trial
摘要
Abstract
Objective To assess the effectiveness and safety of vitaminA(VitA) for Preventing bronchopulmonary dysplasia (BPD) in preterm infants systematically. Methods The PubMed, EMBASE,Cochrane LibraryClinical controlled trial database, Chinese Journals full-text Database (CNKI), Chinese Technological Journals Database (VIP) and Wan Fang Digital Journal Full-text Database were searched for randomised control trials ( RCTS) on whether VitA could prevent BPD in preterm infants (<37 weeks of gestational age) . The retrieval time was from inception to Oct.2017,at the same time, MESH and free words were used to retrieve. The primary outcome was the incidence of BPD and mortality before discharge; secondary outcomes included the rate of retinopathy of prematurity (ROP), patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH), hospitalization time, oxygen time, mechanical ventilation time, adverse reactions during the treatment. Bias risk was assessed based on the Cochrane handbook for systemic reviews. Revman 5.3 software was used for meta-analysis.ResuIts A total of 6 RCTS (both in English) including 1170 preterm infants met the inclusion criteria. The way of administration was intramuscular injection except a study's way was gastric tube. 6 articles all described the method of generating random sequences, all of them referred to allocation concealment, no ending data loss or selective report results, and 5 trials used the double blind method. Meta-analysis showed that the incidence of BPD in VitA group was lower than that in control group [ RR=0.84,95％CI:0.75-0.94] . There was no significant difference in the mortality before discharge[RR=1.04, 95％CI: 0.81-1.34], as well as in the secondary outcomes, including the incidences of ROP, PDA, IVH, adverse reactions, hospitalization time, mechanical ventilation time, and oxygen time, between the two groups. ConcIusion VitA can reduce the incidence of BPD.关键词
维生素A/早产儿/支气管肺发育不良/系统评价/Meta分析/随机对照实验Key words
Vitamin A/Infant/premature/Bronchopulmonary dysplasia/Systematic review/Meta-analysis/Randomized control trial引用本文复制引用
陈丹丹,朱雪萍..早产儿生后补充维生素A可预防支气管肺发育不良:基于6篇随机对照试验的Meta分析[J].中国循证儿科杂志,2017,12(6):429-433,5.基金项目
国家自然基金面上项目:81771626 （）
江苏省自然基金面上项目:BK20141183 （）
苏州市科技局项目:SS201428、SS201644、SYS201440 （）
苏州市卫生和计划生育委员会临床重点病种诊疗技术专项:LCZX201612 （）
江苏省妇幼健康重点人才:FRC201731 （）
