中国中医药信息杂志2018，Vol.25Issue(2)：47-50,4.DOI:10.3969/j.issn.1005-5304.2018.02.011
醒鼻温敏凝胶剂对变应性鼻炎大鼠血清白细胞介素-4、转化生长因子-β1和鼻黏膜嗜酸性粒细胞的影响
Effects of Xingbi Wenmin Gel on Serum Levels of IL-4, TGF-β1 and Nasal Mucosa Eosinophils in Allergic Rhinitis Rats
摘要
Abstract
Objective To observe the effects of Xingbi Wenmin Gel on serum levels of IL-4, TGF-β1 and nasal mucosa eosinophils (EOS) in allergic rhinitis (AR) rats; To discuss its mechanism of action. Methods Intraperitoneal injection of egg albumin and aluminum hydroxide based sensitized to ovalbumin challenge 2％ local AR model was established successfully. The experimental rats were randomly divided into normal group, model group, positive control group, and Xingbi Gel low-, medium-, and high-dosage groups. Each medication group was given relevant medicine for intervention. The rat symptom scores in each group were compared, and serum IL-4, TGF-β1, and nasal mucosa EOS counts were detected. Results Compared with the normal group, the serum levels of IL-4 and TGF-β1 in model group increased significantly (P<0.01), and the nasal mucosa EOS counts increased significantly (P<0.05). Compared with model group, the serum levels of IL-4 and TGF-β1 in Xingbi Gel medium-dosage group and positive control group decreased significantly (P<0.01), and the nasal mucosa EOS counts decreased significantly (P<0.05). Conclusion Xingbi Wenmin Gel may be effective through down-regulation of IL-4, TGF-β1 levels of inflammatory factors, and reduction of EOS infiltration in nasal mucosa.关键词
醒鼻温敏凝胶剂/白细胞介素-4/转化生长因子-β1/嗜酸性粒细胞计数/大鼠Key words
Xingbi Wenmin Gel/IL-4/TGF-β1/eosinophilia counts/rats分类
医药卫生引用本文复制引用
邱彩霞,郑健,林东红,艾斯,吴博,庄翔莉,翁珂涵,李旭微..醒鼻温敏凝胶剂对变应性鼻炎大鼠血清白细胞介素-4、转化生长因子-β1和鼻黏膜嗜酸性粒细胞的影响[J].中国中医药信息杂志,2018,25(2):47-50,4.基金项目
国家自然科学基金(81373820) （81373820）
福建省自然科学基金(2015J01683) （2015J01683）
