中国中医药信息杂志2018，Vol.25Issue(2)：55-58,4.DOI:10.3969/j.issn.1005-5304.2018.02.013
清金颗粒对耐甲氧西林金黄色葡萄球菌感染肺炎模型小鼠的影响
Effects of Qingjin Granules on Methicillin-resistant Staphylococcus Aureus Pneumonia Mice
摘要
Abstract
Objective To observe the effects of Qingjin Granules on methicillin-resistant staphylococcus aureus (MRSA) pneumonia mice. Methods Pneumonia model was prepared by intranasal drip of bacterial fluid. Experimental mice were randomly divided into control group, model group, Western medicine group and TCM group. On the third day after infection, the Western medicine group was treated with linezolid, and the TCM group was given Qingjin Granules for gavage. The control and model group were given the same amount of normal saline for gavage. Body weight and clinical manifestations every day of each mouse after infected were recorded. Lung scans at day 3 and day 10 were taken; the pathological changes trough HE staining were observed; microbial load of lung tissue was detected. Results There were significant weight losses on mice except control group on the first day after infection. CT scan showed that the lung inflammation was filled with mice on the third day after infection. The lung inflammation in the TCM group was more reduced than model group, with less inflammatory exudate and only scattered inflammatory exudates. Meanwhile, pulmonary inflammatory pathology was reduced and the amount of bacteria were reduced in the lungs of TCM group (P<0.05), but it was less effective than linezolid (P<0.05). Conclusion Qingjin Granules can significantly reduce the microbial load of the lung and infiltration of inflammatory cells in lung tissue of mice, achieving the efficacy of treating MRSA pneumonia in mice.关键词
清金颗粒/耐甲氧西林金黄色葡萄球菌/肺炎/小鼠Key words
Qingjin Granules/methicillin-resistant staphylococcus aureus/pneumonia/mice分类
医药卫生引用本文复制引用
张少言,张晔敏,吴定中,马子风,钱家骅,张惠勇,鹿振辉..清金颗粒对耐甲氧西林金黄色葡萄球菌感染肺炎模型小鼠的影响[J].中国中医药信息杂志,2018,25(2):55-58,4.基金项目
国家自然科学基金青年基金(81403353) （81403353）
上海市中医药事业发展三年行动计划(ZY3-CCCX-2-1002) （ZY3-CCCX-2-1002）
