中国中医药信息杂志2018，Vol.25Issue(2)：83-88,6.DOI:10.3969/j.issn.1005-5304.2018.02.019
不同中药物料对丸剂溶出的影响及其体内外评价
Effects of Different Chinese Medicine Materials on Dissolution of Pills and Their in Vitro - in vivo Evaluation
摘要
Abstract
Objective To study the effects of five different kinds of Chinese medicine materials on dissolution of pills; To evaluate their in vitro - in vivo correlation.Methods Five different types of traditional Chinese medicine materials, such as starch, fiber, protein, grease and polysaccharide materials, were selected by uniform design to the proposed 8 model formulation and preparation of pills, and the cumulative release rate and in vivo plasma concentration of berberine hydrochloride were determined by HPLC. The effects of Chinese medicine materials on the drug release behavior of pills in vitro - in vivo were investigated. And the in vitro - in vivo correlation of the pills was evaluated.Results Starch and fiber materials could promote the release of the pills, and protein and grease materials has a blocking effect on the pills dissolution. Polysaccharide materials have no significant effect on the dissolution of the pills. Pills in vitro - in vivo correlation was significant.Conclusion Chinese medicine materials have the characteristics of medicine-assisted unity, which can control the dissolution and bioavailability of pills by adjusting the proportion of powder in the prescription. And the pills have good correlation in vitro - in vivo.关键词
中药物料/盐酸小檗碱/丸剂/溶出/体内外相关性Key words
Chinese medicine materials/berberine hydrochloride/pill/dissolution/correlation in vivo - in vitro分类
医药卫生引用本文复制引用
陈天朝,胡玉青,刘瑞霞,于兰兰,马彦江,常倩倩,李瑞颖..不同中药物料对丸剂溶出的影响及其体内外评价[J].中国中医药信息杂志,2018,25(2):83-88,6.基金项目
河南省教育厅科学技术研究重点项目(13A350597) （13A350597）
河南省科技攻关计划项目(142102310278) （142102310278）
