中华临床免疫和变态反应杂志2017，Vol.11Issue(4)：351-357,7.DOI:10.3969/j.issn.1673-8705.2017.04.000
应用圆柏花粉变应原皮试液诊断圆柏花粉过敏性疾病的有效性和安全性
Accuracy and Safety of Sabina chinensis Pollen Extract Used for Skin Intradermal test in Diagnosis of Sabina chinensis Pollen Allergy
摘要
Abstract
Objective To evaluate the accuracy and safety of Sabina chinensis pollen extract which was used for intradermal test ( IDT) in the diagnosis of Sabina chinensis pollen allergy .Methods 1043 Patients were collected and reviewed from Department of Allergy , Peking Union Medical College Hospital since 2009 Feb to 2009 Jul.All patients were prescribed IDT with Sabina chinensis pollen extract and sIgE detection of Juniperus sabinoides ( t6, UniCAP , Phadia ) .The IDT results were recorded and clinical integrated diagnosis was made by allergists .The accuracy of IDT with Sabina chinensis pollen ex-tract was evaluated by using clinical integrated diagnoses of allergists and sIgE detection results as golden standards respectively .Adverse reactions were also recorded for the evaluation of safety .Results IDT results≥ (+) was defined as the cutoff threshold for diagnosing .Sensitivity , specificity , positive predictive value , negative predictive value , accuracy , and area under ROC curve , were 0.9574 , 0.7145, 0.4018, 0.9882, 0.7550 and 0.891, 95％confidence interval (0.864, 0.918) respective-ly by using clinical integrated diagnoses of allergists as gold standard .Whereas sIgE results ≥0.35 kUA/L was defined as the cutoff threshold for diagnosing , sensitivity , specificity , positive predictive value , nega-tive predictive value, and accuracy were 0.9549, 0.1505, 0.6165, 0.7000, and 0.6239 respective-ly.Only 1 (0.0959％) case was attacked by type Ⅰmild systemic adverse reaction during IDT with Sa-bina chinensis pollen extract .Conclusion IDT with Sabina chinensis pollen extract is an accuracy and safe tool for the diagnosis of Sabina chinensis pollen allergy .关键词
圆柏花粉/皮内试验/有效性/安全性Key words
Sabina chinensis pollen/intradermal test/accuracy/safety引用本文复制引用
李宏,岳凤敏,徐涛,程璇,尹佳,王瑞琦,王良录,孙劲旅,文利平,顾建青,关凯..应用圆柏花粉变应原皮试液诊断圆柏花粉过敏性疾病的有效性和安全性[J].中华临床免疫和变态反应杂志,2017,11(4):351-357,7.基金项目
十一五国家支撑计划(2008BAI59B04),国家重大新药创制科技重大专项(2014ZX09102041),北京市科技计划(Z131100006813047) （2008BAI59B04）
